Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade
The relative contributions of CD28 costimulation restoration versus Treg depletion to clinical response to CTLA4 ICB is a matter of considerable controversy. In this study, we provide compelling data that eTreg depletion is critical to tumor clearance in patients treated with dual PD-1 and CTLA4 ICB.
Authors
- Cheuk Hong Leung (ORCID: https://orcid.org/0000-0002-2531-7739)
- Jack Phan (ORCID: https://orcid.org/0000-0001-5977-6004)
- Renata Ferrarotto (ORCID: https://orcid.org/0000-0002-3561-215X)
- Keiko Akagi (ORCID: https://orcid.org/0000-0002-5159-3403)
- Weihong Xiao (ORCID: https://orcid.org/0000-0003-4132-213X)
- Shengbin Ye (ORCID: https://orcid.org/0000-0001-8767-2595)
- Suyu Liu (ORCID: https://orcid.org/0000-0003-0126-2646)
- Edwin R. Parra (ORCID: https://orcid.org/0000-0001-9068-1636)
- Clifton D. Fuller (ORCID: https://orcid.org/0000-0002-5264-3994)
- Shaoheng Liang (ORCID: https://orcid.org/0000-0002-9575-1522)
- Baohua Sun (ORCID: https://orcid.org/0000-0003-0393-8099)
- Bo Jiang (ORCID: https://orcid.org/0000-0001-8341-1750)
- Adam S. Garden (ORCID: https://orcid.org/0000-0001-7926-2641)
- Qingnan Liang (ORCID: https://orcid.org/0000-0002-2030-1949)
- Neil D. Gross (ORCID: https://orcid.org/0000-0002-9427-0743)
- Michael A. Curran (ORCID: https://orcid.org/0000-0003-4996-7207)
- Michelle D. Williams (ORCID: https://orcid.org/0000-0002-9133-7332)
- Maura L. Gillison (ORCID: https://orcid.org/0000-0002-8145-5749)
- Jason M. Johnson (ORCID: https://orcid.org/0000-0001-7724-5784)
- Jay P. Reddy (ORCID: https://orcid.org/0000-0001-9378-4585)
- Diane D. Liu (ORCID: https://orcid.org/0000-0003-3301-0259)
- Nils-Petter Rudqvist (ORCID: https://orcid.org/0000-0002-9720-3124)
- Miriam N. Lango (ORCID: https://orcid.org/0000-0003-0736-7473)
- Joe Dan Dunn (ORCID: https://orcid.org/0000-0002-5091-4527)
- Xianli Jiang (ORCID: https://orcid.org/0000-0003-1697-8575)
- Satvik Elayavalli
- J. Jack Lee (ORCID: https://orcid.org/0000-0001-5469-9214)
- Ken Chen (ORCID: https://orcid.org/0000-0003-4013-5279)
- Meng Li (ORCID: https://orcid.org/0000-0003-2123-2444)
- Jinzhuang Dou (ORCID: https://orcid.org/0000-0003-0090-4264)
- Shan He (ORCID: https://orcid.org/0009-0003-5844-4755)
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Agenus (United States) (US)
- Yale University (US)
- Boehringer Ingelheim (United States) (US)
- Rice University (US)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-04-18
- DOI
- https://doi.org/10.1158/2159-8290.cd-24-1390
- Citations
- 7
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 7.32