Inhibition of S100A12 Attenuates LPS-Induced Endothelial BarrierDysfunction in HPMECs through the JAK2/STAT3 SignalingPathway
Our results suggested S100A12 to be significantly upregulated in LPSinduced HPMECs; inhibiting S100A12 can alleviate endothelial cell barrier dysfunction through the JAK2/STAT3 signaling pathway and thereby improve LPS-induced HPMECs injury.
Authors
- Wenmin Wang (ORCID: https://orcid.org/0000-0003-2664-4413)
- Xiangming Ye (ORCID: https://orcid.org/0000-0003-2230-6329)
- Lingzhi Jiang (ORCID: https://orcid.org/0000-0003-1047-451X)
- Ye Shen (ORCID: https://orcid.org/0009-0005-2322-5493)
- Hengjie Li (ORCID: https://orcid.org/0000-0003-3066-1208)
- Yanli Zhang (ORCID: https://orcid.org/0000-0003-1481-6361)
- Hui Mao (ORCID: https://orcid.org/0000-0002-0697-7184)
Institutions
- Zhejiang Provincial People's Hospital (CN)
- Hangzhou Medical College (CN)
- Zhejiang University of Technology (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Current Molecular Medicine
- Published
- 2025-04-17
- DOI
- https://doi.org/10.2174/0115665240338945250317082242
- Citations
- 1
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 0.81