Lipidomic analysis coupled with machine learning identifies unique urinary lipid signatures in patients with interstitial cystitis/bladder pain syndrome
Urinary levels of C24 ceramide, along with those of C24 ceramide plus LPI (18:3), could be potential biomarkers for HL. Machine learning-coupled urinary lipidomics may play an important role in the next-generation AI- driven diagnostic systems for IC/BPS.
Authors
- Tomonori Minagawa (ORCID: https://orcid.org/0000-0002-5910-2808)
- Masahiko Sumitani (ORCID: https://orcid.org/0000-0002-3662-8217)
- Jun Kamei (ORCID: https://orcid.org/0000-0002-0069-7392)
- Takuya Iwaki (ORCID: https://orcid.org/0000-0001-5328-3954)
- Akira Nomiya (ORCID: https://orcid.org/0000-0001-6698-8232)
- Yusuke Sato (ORCID: https://orcid.org/0000-0002-6239-6050)
- Satoru Taguchi (ORCID: https://orcid.org/0000-0002-1291-4294)
- Masaki Nakamura (ORCID: https://orcid.org/0000-0003-1859-2342)
- Daisuke Yamada (ORCID: https://orcid.org/0000-0003-1561-5908)
- Hiroshi Fukuhara (ORCID: https://orcid.org/0000-0002-5404-600X)
- Yuta Yamada (ORCID: https://orcid.org/0000-0002-9698-4301)
- Haruki Kume (ORCID: https://orcid.org/0000-0001-9841-0857)
- Yukio Homma (ORCID: https://orcid.org/0000-0002-4794-5250)
- Makoto Kurano (ORCID: https://orcid.org/0000-0002-2596-1145)
- Yoshiyuki Akiyama (ORCID: https://orcid.org/0000-0003-1439-5640)
- Aya Niimi (ORCID: https://orcid.org/0000-0002-4828-7851)
Institutions
- Shinshu University (JP)
- Kyorin University (JP)
- NTT Medical Center (JP)
- University of Tokyo Hospital (JP)
- Japan Organization of Occupational Health and Safety (JP)
- Tokyo Metropolitan Tama Medical Center (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- World Journal of Urology
- Published
- 2025-04-18
- DOI
- https://doi.org/10.1007/s00345-025-05628-y
- Citations
- 1
- Primary Topic
- Urinary Bladder and Prostate Research
- Type
- article
- Field-Weighted Citation Impact
- 1.84
Funders
- Japan Agency for Medical Research and Development
- Shinshu University
- Japan Society for the Promotion of Science