Validation of Senescence of the Role of ATM/P53 Pathway in Myocardial Senescence in Mice with Sepsis
Cellular senescence and immune dysregulation play critical roles in SIMD. Targeting DDR pathways, as demonstrated by KU60019 treatment, provides novel insights into the role of cellular senescence in severe sepsis and its potential therapeutic implications for improving cardiovascular prognosis in septic patients.
Authors
- Fenfen Xia
- Ruilin Ding
- Xuemei Shi
- Zhiqiang Yan (ORCID: https://orcid.org/0000-0003-4714-2076)
- Xiaojie Wang (ORCID: https://orcid.org/0000-0003-4817-5830)
- Yan Du (ORCID: https://orcid.org/0000-0003-4556-8356)
- Qing Peng (ORCID: https://orcid.org/0000-0003-1372-1993)
Institutions
- Affiliated Hospital of Southwest Medical University (CN)
Publication Details
- Journal
- Infection and Drug Resistance
- Published
- 2025-04-01
- DOI
- https://doi.org/10.2147/idr.s505836
- Citations
- 1
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Southwest Medical University
- Affiliated Hospital of Southwest Medical University