Disease burden in inflammatory arthritis: an unsupervised machine learning approach of the COVAD-2 e-survey dataset
Disease burden in inflammatory arthritis is determined by a complex interplay of factors, with physical health status and depression playing crucial roles. The identification of distinct patient clusters suggests the need for a paradigm shift towards more integrated care approaches that equally emphasize physical and mental health, regardless of the underlying diagnosis.
Authors
- Syahrul Sazliyana Shaharir (ORCID: https://orcid.org/0000-0002-9068-8114)
- Lilith Stange Nunez
- Akira Yoshida (ORCID: https://orcid.org/0000-0003-3590-1637)
- Latika Gupta
- Elena Bartoloni (ORCID: https://orcid.org/0000-0003-4776-2136)
- Erick Adrian Zamora Tehozol (ORCID: https://orcid.org/0000-0002-7888-3961)
- Sinan Kardeş (ORCID: https://orcid.org/0000-0002-6311-8634)
- Shinji Sato (ORCID: https://orcid.org/0000-0002-6338-7367)
- Pradeepta Sekhar Patro (ORCID: https://orcid.org/0000-0003-3642-1061)
- Armen Yuri Gasparyan (ORCID: https://orcid.org/0000-0001-8749-6018)
- Arun K. Pande (ORCID: https://orcid.org/0000-0002-9570-1509)
- Döndü Üsküdar Cansu (ORCID: https://orcid.org/0000-0001-6543-3905)
- Imane El bouchti
- Gabriela Arredondo
- José Proaño Bernaola
- Fabiola Atzeni (ORCID: https://orcid.org/0000-0002-9328-3075)
- Sapan C Pandya (ORCID: https://orcid.org/0000-0002-1701-368X)
- Reem Hamdy A Mohammed (ORCID: https://orcid.org/0000-0003-4994-7687)
- Wendy Calapaqui
- Aarat Patel (ORCID: https://orcid.org/0000-0002-9756-2274)
- Lorenzo Cavagna (ORCID: https://orcid.org/0000-0003-3292-1528)
- Vikas Agarwal (ORCID: https://orcid.org/0000-0002-4508-1233)
- Florenzo Iannone (ORCID: https://orcid.org/0000-0003-0474-5344)
- R Naveen
- Abubakar Yerima (ORCID: https://orcid.org/0000-0002-6694-507X)
- Dzifa Dey (ORCID: https://orcid.org/0000-0002-3339-5112)
- Leonardo Santos Hoff (ORCID: https://orcid.org/0000-0002-2083-4796)
- Marie‐Therese Holzer (ORCID: https://orcid.org/0000-0002-2064-6728)
- Suryo Anggoro Kusumo Wibowo (ORCID: https://orcid.org/0000-0002-0089-0504)
- Lisa S Traboco (ORCID: https://orcid.org/0000-0002-1952-7879)
- Gian Domenico Sebastiani (ORCID: https://orcid.org/0000-0003-2969-6649)
- Generoso Guerra Bautista (ORCID: https://orcid.org/0000-0002-6556-1322)
- Julien Campagne (ORCID: https://orcid.org/0000-0002-6186-4334)
- Keerthi Talari Bommakanti
- Prithvi Sanjeevkumar Gaur (ORCID: https://orcid.org/0000-0002-2341-1932)
- Gil Alberto Reyes Llerena
- Arnaud François (ORCID: https://orcid.org/0000-0001-7436-9554)
- Franco Franceschini (ORCID: https://orcid.org/0000-0003-3678-6124)
- James B Lilleker (ORCID: https://orcid.org/0000-0002-9230-4137)
- Hugo Alonzo
- Carlos Benito Santiago Pastelin
- Mrudula Joshi (ORCID: https://orcid.org/0000-0001-7312-351X)
- Yurilís Fuentes-Silva (ORCID: https://orcid.org/0000-0002-5915-769X)
- Rajiv Ranjan
- N. Kimura (ORCID: https://orcid.org/0000-0002-8883-9374)
- Giovanni Orsolini (ORCID: https://orcid.org/0000-0003-4119-3016)
- Stylianos Tomaras (ORCID: https://orcid.org/0000-0002-5923-2557)
- José António Pereira Silva
- Simone Parisi (ORCID: https://orcid.org/0000-0003-4496-8315)
- Victorio Pimentel
- Tsvetelina Velikova (ORCID: https://orcid.org/0000-0002-0593-1272)
- Alejandro Quiñónez Obiols
- Arvind Nune (ORCID: https://orcid.org/0000-0002-3849-614X)
- Javier Merayo‐Chalico (ORCID: https://orcid.org/0000-0002-5870-0523)
- Ajay Asranna
- Okwara Celestine Chibuzo (ORCID: https://orcid.org/0000-0002-7727-5657)
- I. J. Colunga-Pedraza (ORCID: https://orcid.org/0000-0002-2786-5843)
- Dina Arrieta (ORCID: https://orcid.org/0000-0003-4052-7184)
- Wilmer Gerardo Rojas Zuleta
- Manuel F. Ugarte‐Gil (ORCID: https://orcid.org/0000-0003-1728-1999)
- Gianluca Sambataro (ORCID: https://orcid.org/0000-0001-9933-1202)
- Pier Paolo Sainaghi (ORCID: https://orcid.org/0000-0001-8322-9158)
- Sanat Phatak (ORCID: https://orcid.org/0000-0002-3548-9956)
- Carlo V. Caballero‐Uribe (ORCID: https://orcid.org/0000-0002-9845-8620)
- Takahisa Gono (ORCID: https://orcid.org/0000-0002-2593-1771)
- Samuel Katsuyuki Shinjo (ORCID: https://orcid.org/0000-0002-3682-4517)
- Lina El Kibbi
- Carlos Enrique Toro Gutiérrez (ORCID: https://orcid.org/0000-0002-6084-7049)
- Daniele Lini (ORCID: https://orcid.org/0000-0002-5930-3968)
- Melinda Nagy‐Vincze (ORCID: https://orcid.org/0000-0003-0316-3828)
- Vidya Limaye (ORCID: https://orcid.org/0000-0002-8142-9532)
- Hussein Mohammed Halabi (ORCID: https://orcid.org/0000-0002-5174-8292)
- Rodrigo Nicolás Garcia Salinas (ORCID: https://orcid.org/0000-0002-5928-1092)
- Rakesh Kumar Pilania (ORCID: https://orcid.org/0000-0002-9015-1704)
- Abhra Chandra Chowdhury (ORCID: https://orcid.org/0000-0001-5143-0025)
- Ibukunoluwa Dedeke
- Sreoshy Saha (ORCID: https://orcid.org/0000-0001-6745-9770)
- Raquel Aránega
- Sergio Del Vescovo (ORCID: https://orcid.org/0009-0003-8970-7351)
- Marcello Govoni (ORCID: https://orcid.org/0000-0003-0499-5773)
- Jesus Loarce‐Martos (ORCID: https://orcid.org/0000-0003-1352-9539)
- Marcin Milchert (ORCID: https://orcid.org/0000-0002-0943-8768)
- Marco Fornaro (ORCID: https://orcid.org/0000-0003-1716-7432)
- Alain Meyer (ORCID: https://orcid.org/0000-0003-0893-6041)
- Yuko Kaneko (ORCID: https://orcid.org/0000-0003-2646-5765)
- Akanksha Ghodke
- Jonathan Losanto
- Wanruchada Katchamart (ORCID: https://orcid.org/0000-0002-8952-5967)
- Alessandro Giollo (ORCID: https://orcid.org/0000-0001-9355-7673)
- Elisa Palalane
- Jossiell Then Báez
- A Becky
- João Eurico Fonseca (ORCID: https://orcid.org/0000-0003-1432-3671)
- Kunal Chandwar
- Miguel Ángel Saavedra (ORCID: https://orcid.org/0000-0003-0687-9944)
- Ai Lyn Tan (ORCID: https://orcid.org/0000-0002-9158-7243)
- Fabian Proft (ORCID: https://orcid.org/0000-0003-4306-033X)
- Zoha Zahid Fazal (ORCID: https://orcid.org/0000-0002-0464-401X)
- Luca Quartuccio (ORCID: https://orcid.org/0000-0002-0134-6439)
- Mahabaleshwar Mamadapur (ORCID: https://orcid.org/0000-0001-7421-2418)
- Nelly Ziadé (ORCID: https://orcid.org/0000-0002-4479-7678)
- Marco Sebastiani
- Tamer Atef Gheita (ORCID: https://orcid.org/0000-0002-1155-9729)
- Hanan M. Fathi (ORCID: https://orcid.org/0000-0003-1964-305X)
- Karoll Cabriza
- Parikshit Sen (ORCID: https://orcid.org/0000-0002-1630-6026)
- Abraham Edgar Gracia‐Ramos (ORCID: https://orcid.org/0000-0003-1842-2554)
- Merrilee Needham (ORCID: https://orcid.org/0000-0001-6591-1444)
- Binit Vaidya (ORCID: https://orcid.org/0000-0002-4840-8924)
- Antonio Cachafeiro-Vilar (ORCID: https://orcid.org/0000-0002-8219-6814)
- Chengappa Kavadichanda (ORCID: https://orcid.org/0000-0002-3643-3989)
- Álvaro Arbeláez-Cortés (ORCID: https://orcid.org/0000-0001-9167-9204)
- Russka Shumnalieva (ORCID: https://orcid.org/0000-0003-2321-6536)
- Zoltán Griger (ORCID: https://orcid.org/0000-0002-1371-7911)
- Daman Langguth (ORCID: https://orcid.org/0000-0002-5706-2347)
- Yogesh Preet Singh (ORCID: https://orcid.org/0000-0003-1258-0041)
- Sergio Prieto‐González (ORCID: https://orcid.org/0000-0003-3179-597X)
- Oliver Distler (ORCID: https://orcid.org/0000-0002-0546-8310)
- Vishwesh Agarwal (ORCID: https://orcid.org/0000-0002-0986-8354)
- Luis Javier Cajas Santana (ORCID: https://orcid.org/0000-0002-4912-7657)
- Laura Andréoli (ORCID: https://orcid.org/0000-0002-9107-3218)
- Rudra Prosad Goswami (ORCID: https://orcid.org/0000-0001-8670-1745)
- Lyn Chinchay
- Ashish Jacob Mathew (ORCID: https://orcid.org/0000-0002-2061-2042)
- Ignacio de la Torre (ORCID: https://orcid.org/0000-0002-1805-634X)
- Rossella De Angelis (ORCID: https://orcid.org/0000-0001-5169-3511)
- Hector Chinoy (ORCID: https://orcid.org/0000-0001-6492-1288)
- Ran Nakashima (ORCID: https://orcid.org/0000-0001-6247-0647)
- Airenakho Emorinken (ORCID: https://orcid.org/0000-0002-3306-572X)
- Ghita Harifi
- Jessica Day (ORCID: https://orcid.org/0000-0001-8528-4361)
- Nilmo Chávez (ORCID: https://orcid.org/0000-0002-4158-1468)
- Phonpen Akarawatcharangura Goo (ORCID: https://orcid.org/0009-0009-7611-9992)
- Olena Zimba (ORCID: https://orcid.org/0000-0002-4188-8486)
- Alessia Alunno (ORCID: https://orcid.org/0000-0003-1105-5640)
- Nicoletta Del Papa (ORCID: https://orcid.org/0000-0003-1549-8852)
- Nelly Colaman
- Enrico Fusaro (ORCID: https://orcid.org/0000-0001-9888-2563)
- Masataka Kuwana (ORCID: https://orcid.org/0000-0001-8352-6136)
- Padnamabha Shenoy
- Bhupen Barman (ORCID: https://orcid.org/0000-0002-5433-1310)
- Margherita Giannini (ORCID: https://orcid.org/0000-0002-4834-5804)
- Mahnoor Javaid (ORCID: https://orcid.org/0000-0002-1501-1031)
- Or Aharonov
- Hakeem Olaosebikan (ORCID: https://orcid.org/0000-0003-4004-0093)
- Ouma Devi Koussougbo (ORCID: https://orcid.org/0000-0002-9049-6323)
- Ho So
- Andrea Bran Ordóñez (ORCID: https://orcid.org/0000-0002-8758-7021)
- Nilesh Srivastav (ORCID: https://orcid.org/0000-0002-1015-9280)
- Tulika Chatterjee (ORCID: https://orcid.org/0000-0001-8844-851X)
- A T M Tanveer Hasan (ORCID: https://orcid.org/0000-0002-5332-3319)
- Johannes Knitza (ORCID: https://orcid.org/0000-0001-9695-0657)
- Reşit Yıldırım
- Jorge Rojas‐Serrano (ORCID: https://orcid.org/0000-0001-6980-7898)
- Zineb Baba
- Ivonne Quezada
- Ihsane Hmamouchi (ORCID: https://orcid.org/0000-0003-4402-5034)
- Océane Landon‐Cardinal (ORCID: https://orcid.org/0000-0002-3361-6165)
- Silvia Grignaschi
- Chris Wincup (ORCID: https://orcid.org/0000-0002-8742-8311)
- Radames Sierra-Zorita
- Margarita Aleksandrovna Gromova (ORCID: https://orcid.org/0000-0002-3757-058X)
- Ioannis Parodis (ORCID: https://orcid.org/0000-0002-4875-5395)
- Vincenzo Venerito (ORCID: https://orcid.org/0000-0002-2573-5930)
- Enrique Julio Giraldo Ho
- Karen Ingrid Schreiber (ORCID: https://orcid.org/0000-0003-0660-7690)
- Ashima Makol (ORCID: https://orcid.org/0000-0002-8748-898X)
- Eduardo Romero Hidalgo
- John D Pauling (ORCID: https://orcid.org/0000-0002-2793-2364)
- Kshitij Jagtap (ORCID: https://orcid.org/0000-0003-2729-737X)
- Bohdana Doskaliuk (ORCID: https://orcid.org/0000-0003-1650-8928)
- Babur Salim (ORCID: https://orcid.org/0000-0001-8430-9299)
- Naitica Darooka (ORCID: https://orcid.org/0000-0002-5577-7541)
- Praggya Yaadav (ORCID: https://orcid.org/0000-0003-4372-2540)
- Manoj M Manesh
- Yi‐Ming Chen (ORCID: https://orcid.org/0000-0001-7593-3065)
- Aman Sharma (ORCID: https://orcid.org/0000-0001-7949-1049)
- Vikas Gupta (ORCID: https://orcid.org/0000-0002-2089-027X)
- Avinash Jain (ORCID: https://orcid.org/0000-0003-4733-5142)
- Chou Luan Tan (ORCID: https://orcid.org/0000-0002-9859-5385)
- Anuj Shukla
- Vergara M Cristian
- Escalante M Idania
- Sajal Ajmani
- Ricardo Saénz
- Marie Hudson
- Maria Giovanna Danielli
- Uyi Ima-Edomwonyi
- Nwankwo Henry Madu
Institutions
- University of Leeds (GB)
- Siriraj Hospital (TH)
- Sanjay Gandhi Post Graduate Institute of Medical Sciences (IN)
- Mexican Social Security Institute (MX)
- Universidade de São Paulo (BR)
- Saint Joseph University (LB)
- King Edward Memorial Hospital and Seth G.S. Medical College (IN)
- Walter and Eliza Hall Institute of Medical Research (AU)
- B. J. Medical College & Sassoon Hospital (IN)
- University of Pavia (IT)
- Mahidol University (TH)
- University of Manchester (GB)
- Maulana Azad Medical College (IN)
- Mahatma Gandhi Mission Medical College and Hospital (IN)
- NIHR Leeds Musculoskeletal Biomedical Research Unit (GB)
- Hospital Clínic de Barcelona (ES)
- Hôtel-Dieu de Paris (FR)
- Policlinico San Matteo Fondazione (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- The Royal Wolverhampton NHS Trust (GB)
- Wolverhampton Hospital (GB)
- Memorial Hospital (US)
- University of Bari Aldo Moro (IT)
- Sofia University "St. Kliment Ohridski" (BG)
- Mymensingh Medical College Hospital (BD)
- University of Birmingham (GB)
- Pomeranian Medical University (PL)
- Nippon Medical School (JP)
Publication Details
- Journal
- Rheumatology Advances in Practice
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1093/rap/rkaf031
- Citations
- 1
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 1.67