Emerging zoonotic potential of H4N1 avian influenza virus: enhanced human receptor binding and replication via novel mutations
In summary, our study provides preliminary experimental evidence for the emerging zoonotic potential of H4N1 AIV. These findings expand our knowledge of the H4 subtype AIV and reinforce the critical need for continued surveillance of AIV to prevent and prepare for potential outbreaks affecting human health.
Authors
- Xumei Li (ORCID: https://orcid.org/0000-0002-0706-6542)
- Zhangping Tan
- Zhentao Yu (ORCID: https://orcid.org/0000-0002-5785-8492)
- Jing Deng (ORCID: https://orcid.org/0000-0002-1736-1801)
- Yun Tang (ORCID: https://orcid.org/0000-0003-0211-7360)
- Xiaobin Peng (ORCID: https://orcid.org/0000-0003-1537-0795)
- Yang Liu (ORCID: https://orcid.org/0000-0002-0712-9750)
- Ping Liu (ORCID: https://orcid.org/0000-0002-2899-3732)
- Ming Yuan (ORCID: https://orcid.org/0000-0003-3761-3073)
- XuBin Du
- Han Yang
- Feng Yin (ORCID: https://orcid.org/0000-0001-7407-9047)
- Gang Jiang (ORCID: https://orcid.org/0000-0003-0563-3870)
- Shuang Chen (ORCID: https://orcid.org/0009-0008-1028-4090)
- Yunqiu Zhou
- Xianxian Wen
Institutions
- Chongqing Maternal and Child Health Hospital (CN)
- Taiwan Centers for Disease Control (TW)
Publication Details
- Journal
- Virology Journal
- Published
- 2025-04-18
- DOI
- https://doi.org/10.1186/s12985-025-02736-4
- Primary Topic
- Influenza Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00