Self- and Informant-Report Cognitive Decline Discordance and Mild Cognitive Impairment Diagnosis
In this cross-sectional study of 1200 dyads, measures of ECog score discordance helped distinguish CU from MCI individuals with high specificity. Participant and study partner agreement on lack of observed changes in the participant was associated with lower likelihood of MCI, highlighting the value of dyadic discordance metrics for ruling out MCI in diverse settings.
Authors
- Rachana Tank (ORCID: https://orcid.org/0000-0002-4771-6685)
- Juliet Fockler
- Diana Truran (ORCID: https://orcid.org/0000-0001-7159-2216)
- Miriam T. Ashford (ORCID: https://orcid.org/0000-0003-4045-6435)
- Jae Myeong Kang (ORCID: https://orcid.org/0000-0003-0803-9332)
- R. Scott Mackin (ORCID: https://orcid.org/0000-0001-8072-476X)
- Derek Flenniken
- Patrizia Vannini (ORCID: https://orcid.org/0000-0002-9425-1059)
- Chengshi Jin (ORCID: https://orcid.org/0000-0002-6431-790X)
- Manchumad Manjavong (ORCID: https://orcid.org/0000-0002-9334-5571)
- Joseph Eichenbaum (ORCID: https://orcid.org/0000-0003-1841-5936)
- Anna Aaronson (ORCID: https://orcid.org/0000-0002-5231-9684)
- Melanie J. Miller (ORCID: https://orcid.org/0000-0002-7189-1109)
- Rachel L. Nosheny (ORCID: https://orcid.org/0000-0003-4995-8319)
- Bernard Landavazo
- Michael Walter Weiner (ORCID: https://orcid.org/0000-0002-0144-1954)
- Monica R. Camacho
- Adam Diaz
- Sarah Tomaszewski Farias (ORCID: https://orcid.org/0009-0009-8969-3387)
Institutions
- Gachon University (KR)
- Brigham and Women's Hospital (US)
- San Francisco VA Medical Center (US)
- Harvard University (US)
- Khon Kaen University (TH)
- University of California, San Francisco (US)
- Massachusetts General Hospital (US)
- UK Dementia Research Institute (GB)
- Advanced Imaging Research (United States) (US)
- Northern California Institute for Research and Education (US)
- University College London (GB)
- University of California, Davis (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-04-18
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.5810
- Citations
- 4
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 5.88
Funders
- U.S. Department of Defense
- Foundation for the National Institutes of Health
- Alzheimer's Association
- Larry L. Hillblom Foundation
- Bristol-Myers Squibb
- Eli Lilly and Company
- California Department of Public Health
- Biogen
- Patient-Centered Outcomes Research Institute
- Meso Scale Diagnostics
- Alzheimer's Disease Neuroimaging Initiative
- BioClinica
- Northern California Institute for Research and Education
- Australian Catholic University
- Eisai
- H. Lundbeck A/S
- IXICO
- National Institutes of Health
- Genentech
- Canadian Institutes of Health Research
- National Institute on Aging
- National Institute of Mental Health
- Johnson and Johnson Pharmaceutical Research and Development
- Janssen Alzheimer Immunotherapy Research And Development