NMN Supplementation Inhibits Endothelial Cell ROS-Mediated Src/Pi3k/Akt Signaling Pathway to Protect High-Altitude Blood-Retinal Barrier
These findings establish the role of NMN and the ROS-mediated Src/Pi3k/Akt signaling pathway in protecting the endothelial barrier, and identify a potential therapeutic strategy for protecting against hypoxia-related BRB leakage.
Authors
- Ning Du (ORCID: https://orcid.org/0000-0001-5394-8776)
- Keke Ge (ORCID: https://orcid.org/0000-0003-1801-7911)
- Jiayue Hu (ORCID: https://orcid.org/0000-0002-7041-8897)
- Siyuan Liu (ORCID: https://orcid.org/0000-0002-0255-8847)
- Wenfang Zhang (ORCID: https://orcid.org/0000-0002-5478-9145)
Institutions
- Lanzhou University Second Hospital (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-04-18
- DOI
- https://doi.org/10.1167/iovs.66.4.51
- Citations
- 7
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 7.82