Countywide burden, pathology, and genetics of lethal hypertrophic cardiomyopathy: from the POST SCD study
In this 11-year countywide post-mortem study, HCM meeting pathologic, clinical, or genetic criteria was associated with autopsy-confirmed arrhythmic cause of sudden death, accounting for 2% of SADs up to age 90, highest in cases <35 years old. Since 85% of cases were undiagnosed before pSCD, the true burden of HCM-related sudden death may be substantially underestimated.
Authors
- Zian H. Tseng (ORCID: https://orcid.org/0000-0001-5996-4099)
- Ellen Moffatt (ORCID: https://orcid.org/0000-0002-3804-3116)
- Francesca N. Delling (ORCID: https://orcid.org/0000-0002-5224-4096)
- Leila Haghighat (ORCID: https://orcid.org/0000-0002-7857-0789)
- Theodore P. Abraham (ORCID: https://orcid.org/0000-0003-3411-1334)
- Andrew J. Connolly (ORCID: https://orcid.org/0000-0002-0660-3270)
Institutions
- Office of Chief Medical Examiner (US)
- University of California, San Francisco (US)
- Office of the Chief Medical Examiner (CA)
Publication Details
- Journal
- EP Europace
- Published
- 2025-04-18
- DOI
- https://doi.org/10.1093/europace/euaf088
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute