Volumetric and diffusion MRI longitudinal patterns in brain metastases after laser interstitial thermal therapy
Question Laser interstitial thermal therapy (LITT) is an emerging local treatment for brain metastases, but the radiographic patterns following this treatment have not been thoroughly described. Findings Responding lesions showed a typical radiographic pattern with early volumetric enlargement and diffusion restriction (not exclusive of responders), followed by a bi-exponential shrinkage and diffusion elevation. Clinical relevance Being aware of the typical radiographic changes in brain metastases responding to LITT is informative for the interpretation of follow-up images. Early volumetric and diffusion changes (< 3-4 months) do not appear to be reliable markers to predict treatment success.
Authors
- Nader Pouratian (ORCID: https://orcid.org/0000-0002-0426-3241)
- Noriko Salamon (ORCID: https://orcid.org/0000-0002-3520-9467)
- Richard G. Everson (ORCID: https://orcid.org/0000-0003-2809-3061)
- Benjamin M. Ellingson (ORCID: https://orcid.org/0000-0002-2764-6640)
- Guoqiang Shao (ORCID: https://orcid.org/0000-0002-3277-6933)
- Jingwen Yao (ORCID: https://orcid.org/0000-0002-8828-1841)
- Gianluca Nocera (ORCID: https://orcid.org/0000-0002-8499-5257)
- Francesco Sanvito (ORCID: https://orcid.org/0000-0003-3379-9958)
- Isaac Yang (ORCID: https://orcid.org/0000-0002-5176-5615)
- Nicholas S. Cho (ORCID: https://orcid.org/0000-0002-8686-0575)
- Zexi Wang
- Catalina Raymond (ORCID: https://orcid.org/0000-0003-2757-439X)
- Kunal Patel (ORCID: https://orcid.org/0000-0002-9854-9178)
- Ashley Teraishi (ORCID: https://orcid.org/0009-0004-3442-8109)
- Won Bae Kim (ORCID: https://orcid.org/0000-0003-3423-3825)
Institutions
- Vita-Salute San Raffaele University (IT)
- University of California, Los Angeles (US)
- Ronald Reagan UCLA Medical Center (US)
- UCLA Medical Center (US)
- Southwestern Medical Center (US)
- Neurobehavioral Systems (US)
- IRCCS Ospedale San Raffaele (IT)
- Samueli Institute (US)
- Neurological Surgery (US)
- Harbor–UCLA Medical Center (US)
- Imaging Center (US)
- Southwestern Medical Center (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- European Radiology
- Published
- 2025-04-18
- DOI
- https://doi.org/10.1007/s00330-025-11587-0
- Citations
- 3
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- Foundation for the National Institutes of Health
- National Institutes of Health
- University of California, Los Angeles
- National Cancer Institute
- National Institute of General Medical Sciences