Circulatory prostate cancer proteome landscapes and prognostic biomarkers in metastatic castrate resistant prostate cancer
Plasma proteome profiling can identify novel circulatory DEPs associated with mCRPC state survivals. Overexpression of RRM2 is linked to poor mCRPC survival and its inclusion alongside conventional prognostic factors enhances the predictive performance of the prognostic model.
Authors
- Bogdana Schmidt (ORCID: https://orcid.org/0000-0002-1233-1638)
- Matt Larsen
- Sumati Gupta (ORCID: https://orcid.org/0000-0001-6271-0831)
- Jincheng Shen (ORCID: https://orcid.org/0000-0002-6551-3558)
- Aik Choon Tan (ORCID: https://orcid.org/0000-0003-2955-8369)
- Anna Neibling
- Claire Hanson (ORCID: https://orcid.org/0000-0002-6706-9091)
- Manish Kohli (ORCID: https://orcid.org/0000-0002-9735-6614)
- Benjamin Louis Maughan (ORCID: https://orcid.org/0000-0002-0010-8551)
- Umang Swami (ORCID: https://orcid.org/0000-0003-3518-0411)
- Skyler B. Johnson (ORCID: https://orcid.org/0000-0002-8881-7706)
- Jonathan D. Tward (ORCID: https://orcid.org/0000-0001-7765-4473)
- Benjamin Haaland (ORCID: https://orcid.org/0000-0002-6270-6303)
- Brock O’Neil (ORCID: https://orcid.org/0000-0002-1497-5824)
- Jennifer Lloyd (ORCID: https://orcid.org/0000-0002-5566-167X)
- Muhammad Zaki Hidayatullah Fadlullah (ORCID: https://orcid.org/0000-0002-3111-8090)
- Tengda Lin (ORCID: https://orcid.org/0000-0001-5147-8432)
- Christopher Dechet (ORCID: https://orcid.org/0000-0002-0534-6006)
- Liang Wang (ORCID: https://orcid.org/0000-0003-2244-7535)
- Hyejung Lee (ORCID: https://orcid.org/0000-0002-5293-4134)
- Enos Ampaw
Institutions
- University of Utah (US)
- Huntsman Cancer Institute (US)
- Moffitt Cancer Center (US)
Publication Details
- Journal
- Clinical Proteomics
- Published
- 2025-04-18
- DOI
- https://doi.org/10.1186/s12014-025-09536-6
- Citations
- 1
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Huntsman Cancer Institute