Pharmacokinetics of Matrine in blood and prostate tissue: a microdialysis-HPLC study in a rabbit model

KangFuXiaoYan suppository exhibits therapeutic potential for chronic prostatitis (CP) ,however, its in vivo pharmacokinetic process remains to be elucidated. This study investigated the pharmacokinetics of Matrine, the primary bioactive component of KangFuXiaoYan suppository, using high-performance liquid chromatography (HPLC) with microdialysis in rabbits. The results showed that the C max of Matrine in jugular vein and prostate tissue were (86.92 ± 2.66) and (45.33 ± 3.65) mg L -1 ,the T max were (30 ± 0.00) and (45 ± 0.00) min, the T 1/2 were (23.55 ± 1.76) and (26.50 ± 5.57) min, the AUC 0-t were (4192.77 ± 67.85) and (2919.78 ± 40.17) mg min L -1 ,the MRT 0-t were (48.90 ± 0.13)and (56.25 ± 1 .06) min. Matrine absorption, distribution, and penetration into prostate tissue were quantified. The results demonstrated rapid absorption into blood and prostate tissue, achieving a penetration rate of 73 %, suggesting potential therapeutic effectiveness for chronic prostatitis treatment. These findings provided experimental support for the clinical application of rectally administered KangFuXiaoYan suppository.