The importance of identifying new and putative target antigens associated with membranous nephropathy: evidence from a Sardinian cohort
Our study highlights at least two interesting considerations. First, the determination of PLA2R on renal tissue in the diagnosis of PLA2R-associated MN is emphasized since 50% of our cases were falsely diagnosed with PLA2R-negative MN based on the serum anti-PLA2R antibodies determination. Second, our study shows six patients with MN likely associated with putative antigens, two of them showing new antigens never described before in literature (HYAL1 and THBS1). This high prevalence of putative antigens in our cohort is not easily explainable and paves the way for evaluating specific factors in the Sardinian population that could explain this evidence.
Authors
- Doloretta Piras
- Gianfranca Cabiddu (ORCID: https://orcid.org/0000-0003-1145-7404)
- Daniela Onnis
- Matteo Floris (ORCID: https://orcid.org/0000-0001-5557-9791)
- Nicola Lepori (ORCID: https://orcid.org/0000-0002-3133-6565)
- R. Mascia (ORCID: https://orcid.org/0000-0002-7174-0220)
- Sanjeev Sethi (ORCID: https://orcid.org/0000-0002-4536-7709)
- Fernando C. Fervenza (ORCID: https://orcid.org/0000-0002-9952-209X)
- Paola Del Bianco (ORCID: https://orcid.org/0000-0002-6597-0265)
- Andrea Angioi (ORCID: https://orcid.org/0000-0001-8311-5409)
- Antonello Pani (ORCID: https://orcid.org/0000-0003-2811-7887)
- Benjamin J. Madden
Institutions
- Mayo Clinic (US)
- University of Cagliari (IT)
- Mayo Clinic in Arizona (US)
- Azienda Ospedaliera G. Brotzu (IT)
Publication Details
- Journal
- Clinical Kidney Journal
- Published
- 2025-04-18
- DOI
- https://doi.org/10.1093/ckj/sfaf115
- Citations
- 1
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 1.43