Insight on the relationship between heart rate variability parameters and the risk of stroke among non-valvular paroxysmal atrial fibrillation patients

This study found that abnormal variation in HRV parameters was more observed in patients with acute ischemic stroke. Then, unlike previous research, this study uniquely integrated multiple HRV parameters to develop novel indices such as AVTD, AVFD, AVA, and CDV, which somehow demonstrated a significant association with the risk of AIS. These new metrics, combined with conventional risk factors and CHA2DS2-VASc score, brought great improvement to the model prediction for AIS risk.