MIR155HG suppresses the osteogenic differentiation of bone marrow mesenchymal stem cells through regulating miR-155-5p and DKK1 expression
MIR155HG suppressed the osteoblastic differentiation of BMSCs by regulating miR-155-5p and DKK1 expression. Either inhibition of miR-155-5p and DKK1 or direct suppression of MIR155HG may be effective approaches for treating PMOP.
Authors
- Cheng‐Han Yang (ORCID: https://orcid.org/0000-0001-7517-3799)
- J Z Xu (ORCID: https://orcid.org/0009-0005-6314-2123)
- Weimin Li (ORCID: https://orcid.org/0000-0003-0985-0311)
- Di Ran (ORCID: https://orcid.org/0000-0002-6282-8722)
- Chunqing Wang (ORCID: https://orcid.org/0000-0002-5532-7962)
Institutions
- Guiyang Medical University (CN)
- Guizhou Cancer Hospital (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-04-19
- DOI
- https://doi.org/10.1186/s13018-025-05798-w
- Citations
- 2
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China
- Guizhou Medical University