Inhibitory activity of amyloid-β aggregation by flavonoids and rosmarinic acid related compounds isolated from <i>Zostera marina</i>
The amyloid β (Aβ) aggregation inhibitory activity of compounds isolated from eelgrass (Zostera marina) was evaluated, and it was found that in the flavonoid compounds, when the hydroxy substituent was replaced by methoxy or sulfate, the activity weakened in that order. The efficacy of rosmarinic acid treatment against mutant nematodes was also evaluated.
Authors
- Atushi Tanaka (ORCID: https://orcid.org/0000-0002-1070-6336)
- Mitsuhiro Sekiguchi (ORCID: https://orcid.org/0000-0001-6780-4538)
- Yuta Tozawa
- Yuki Yamada (ORCID: https://orcid.org/0000-0002-7191-7129)
- Mizuki Horiuchi
- Yasuki Higashimura (ORCID: https://orcid.org/0000-0003-0540-4306)
- Hideyuki Shigemori (ORCID: https://orcid.org/0000-0001-9778-8057)
Institutions
- University of Tsukuba (JP)
- Ishikawa Prefectural University (JP)
- Tsukuba University of Technology (JP)
Publication Details
- Journal
- Bioscience Biotechnology and Biochemistry
- Published
- 2025-04-18
- DOI
- https://doi.org/10.1093/bbb/zbaf058
- Citations
- 2
- Primary Topic
- Phytochemistry and Biological Activities
- Type
- article
- Field-Weighted Citation Impact
- 3.50