Detection by Nasopharyngeal Swabs Alone Underestimates Respiratory Syncytial Virus–Related Hospitalization Incidence in Adults: The Multispecimen Study's Final Analysis
RSV detection increased >100% using 4 specimen types, suggesting a 2-fold correction factor is appropriate for incidence and prevalence studies relying on NPS alone. Saliva was more sensitive than NPS, warranting further study, particularly in cardiac cases.
Authors
- Allison McGeer (ORCID: https://orcid.org/0000-0001-5647-6137)
- Ashley M Wilde (ORCID: https://orcid.org/0000-0001-8459-0025)
- Sonal Uppal
- Thomas Chandler (ORCID: https://orcid.org/0000-0002-2284-6213)
- Paula Peyrani (ORCID: https://orcid.org/0000-0001-8958-1734)
- Alan D. Junkins (ORCID: https://orcid.org/0009-0000-3871-3653)
- Caroline Kassee
- Negar Aliabadi (ORCID: https://orcid.org/0000-0002-9264-5089)
- Kevin Katz
- Samira Mubareka (ORCID: https://orcid.org/0000-0001-5012-2311)
- Julio A. Ramírez (ORCID: https://orcid.org/0000-0001-7801-5374)
- Malak Elsobky (ORCID: https://orcid.org/0009-0003-3175-7823)
- Kari Yacisin
- Warren V. Kalina
- Luis Jódar (ORCID: https://orcid.org/0000-0003-1246-530X)
- Elizabeth Begier (ORCID: https://orcid.org/0000-0002-1287-5416)
- Ruth Carrico (ORCID: https://orcid.org/0000-0003-4319-7694)
- Edward E. Walsh (ORCID: https://orcid.org/0000-0002-8792-8877)
- Stephen Furmanek (ORCID: https://orcid.org/0000-0001-9112-2860)
- Christie Vermeiren
- Ann Regina Falsey (ORCID: https://orcid.org/0000-0002-7141-9701)
- Zoë Zhong
- Qing Liu (ORCID: https://orcid.org/0000-0003-3733-9078)
- Elisa Gonzalez
- Robin Hubler
- Bradford D Gessner
Institutions
- Sunnybrook Health Science Centre (CA)
- University of Louisville (US)
- Pfizer (United States) (US)
- Norton Healthcare (US)
- Sinai Health System (CA)
- Pfizer (Canada) (CA)
- Pfizer (Ireland) (IE)
- Sunnybrook Hospital (CA)
- Sunnybrook Research Institute
- University of Rochester (US)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1093/infdis/jiaf204
- Citations
- 14
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 18.96
Funders
- Pfizer