Potential prognostic markers of cellular senescence in age-associated cardiovascular pathology

The review addresses the issue of cellular senescence, its impact on the development of age-associated cardiovascular diseases, and its prognostic perspective. We appreciated the relationship between cellular senescence and overall organismal aging, focusing on endothelial dysfunction in cardiac patients. The review also discusses the manifestations of cellular aging and highlights their markers that can be used for comprehensive diagnosis and prediction of the risk of acute cardiovascular events. The potential and limitations of senolytic therapy for eliminating senescent cells and reducing systemic inflammation are discussed. The review emphasizes the importance of developing new methods for identifying markers of cellular senescence and implementing personalized approaches in the treatment of age-associated cardio- vascular diseases within the framework of modern precision medicine.