Typhoid Fever Presenting With Cerebral Venous Thrombosis: A Report of a Rare Case

Typhoid fever, caused by <i>Salmonella typhi</i>, is a significant infectious disease in endemic regions. Although it primarily affects the gastrointestinal system, systemic complications, including vascular thrombosis, can occur. We present the case of a 47-year-old previously healthy woman who developed diarrhea, vomiting, and headache in the context of fever, complicated by altered consciousness. Contrast-enhanced computed tomography revealed sagittal sinus thrombosis. Blood cultures were negative for <i>Salmonella</i>, but Widal and Felix serologic testing was positive. The patient was successfully treated with antibiotics and anticoagulants. <i>S. typhi</i> can, in rare cases, lead to cerebral thrombotic events by inducing a hypercoagulable state through inflammation and endothelial dysfunction. This case highlights the rare association of <i>S. typhi</i> infection with cerebral venous thrombosis, emphasizing the importance of considering this etiology in similar clinical presentations.