Exploring the Prognostic and Predictive Impact of Genomic Loss of Heterozygosity and Homologous Recombination Deficiency Alterations in Patients With Metastatic Colorectal Cancer
In pMMR/MSS mCRC, gLOH-high was associated with worse prognosis and higher benefit from the addition of anti-PD-L1 agents to chemotherapy. If confirmed in larger series, these results may inform the design of clinical trials.
Authors
- Eleonora Gusmaroli
- Veronica Conca (ORCID: https://orcid.org/0000-0001-7713-4005)
- Marco Maria Germani (ORCID: https://orcid.org/0000-0002-1036-5869)
- Stefano Tamberi (ORCID: https://orcid.org/0000-0002-7087-9116)
- Clara Ugolini (ORCID: https://orcid.org/0000-0002-3489-8280)
- Mirella Giordano (ORCID: https://orcid.org/0009-0003-0445-4501)
- Lisa Salvatore (ORCID: https://orcid.org/0000-0003-3864-0719)
- Roberto Moretto (ORCID: https://orcid.org/0000-0001-8456-9269)
- Mario Scartozzi (ORCID: https://orcid.org/0000-0001-5977-5546)
- Sara Lonardi (ORCID: https://orcid.org/0000-0002-7593-8138)
- Rossella Bruno (ORCID: https://orcid.org/0000-0003-4965-1501)
- Gianluca Masi (ORCID: https://orcid.org/0000-0001-8329-8989)
- Alessandro Minelli (ORCID: https://orcid.org/0000-0003-3387-1489)
- Martina Carullo (ORCID: https://orcid.org/0000-0003-2846-2517)
- Daniele Rossini (ORCID: https://orcid.org/0009-0000-3777-8471)
- Filippo Pietrantonio (ORCID: https://orcid.org/0000-0002-8530-8420)
- Carlotta Antoniotti (ORCID: https://orcid.org/0000-0001-6881-3188)
- Maria Caterina De Grandis
- Chiara Cremolini (ORCID: https://orcid.org/0000-0002-0520-4841)
- Alessandro Passardi (ORCID: https://orcid.org/0000-0002-7099-240X)
Institutions
- Università Cattolica del Sacro Cuore (IT)
- University of Pisa (IT)
- University of Padua (IT)
- University of Cagliari (IT)
- Agostino Gemelli University Polyclinic (IT)
- Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IT)
- Azienda Unità Sanitaria Locale Della Romagna (IT)
- Istituto Oncologico Veneto (IT)
- Ospedale San Paolo (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Azienda Ospedaliera Universitaria Pisana (IT)
- University of Florence (IT)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1200/po-24-00567
- Primary Topic
- PARP inhibition in cancer therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00