Palladium-Catalyzed Ring-Opening Defluorinative Hiyama Cross-Coupling of <i>gem</i>-Difluorocyclopropanes with Arylsilanes
We report an efficient palladium-catalyzed ring-opening defluorinative Hiyama cross-coupling of <i>gem</i>-difluorocyclopropanes with structurally diverse (hetero)arylsilanes through C-C bond activation and C-F bond cleavage. This regioselective ring-opening defluorinative Hiyama cross-coupling features a broad substrate scope with excellent functional group compatibility, affording a diverse variety of linear 2-fluoroallylic scaffolds in good yields with high <i>Z</i>-selectivity.
Authors
- Hongfang Li (ORCID: https://orcid.org/0000-0002-4281-4737)
- Teck‐Peng Loh (ORCID: https://orcid.org/0000-0002-2936-337X)
- Zimin Wang
- Mingzhu Lu (ORCID: https://orcid.org/0000-0002-6333-0803)
- Daniel C. Hong
Institutions
- Nanyang Technological University (SG)
- Henan University of Technology (CN)
- Huaiyin Normal University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-04-18
- DOI
- https://doi.org/10.1021/acs.joc.5c00564
- Citations
- 4
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 3.16
Funders
- National Natural Science Foundation of China