NeuroCSF: an fMRI method to measure contrast sensitivity function in human visual cortex

The contrast sensitivity function (CSF) describes a range of spatial frequencies (SFs) that are detectable at a given level of contrast and is a very valuable tool both in clinical and fundamental research. However, despite its immense value, the full potential of the CSF has not been utilized in every aspect of clinical research due to time limits and patient factors. We propose neuroCSF as a new method for measuring the CSF across the visual field directly from brain activity and with minimal demand from participants. NeuroCSF is a computational model that estimates voxel-wise CSF parameters (i.e., peak contrast sensitivity, peak spatial frequency, and spatial frequency bandwidth) from functional magnetic resonance imaging (fMRI) signals under controlled visual stimulation conditions. The approach extends the population spatial frequency tuning (Aghajari S, Vinke LN, Ling S. <i>J Neurophysiol</i> 123: 773-785, 2020) and population receptive field (Dumoulin SO, Wandell BA. <i>Neuroimage</i> 39: 647-660, 2008) methods to provide the first characterization of a full CSF using neuroimaging. We observe that across early visual areas (V1, V2, and V3), the CSF peak spatial frequency and spatial frequency cutoff are significantly higher for foveal eccentricity and decrease at parafoveal eccentricities. Conversely, SF bandwidth slowly increases with eccentricity, while peak contrast sensitivity remains constant with eccentricity for all early visual areas. Thus cortical CSF estimates vary systematically with eccentricity. The neuroCSF approach opens new perspectives for the study of cortical visual functions in various disorders where the CSF is impacted, such as amblyopia, traumatic brain injury, and multiple sclerosis.<b>NEW & NOTEWORTHY</b> We introduce neuroCSF, a novel functional magnetic resonance imaging (fMRI)-based method for estimating contrast sensitivity function (CSF) parameters across the visual field. This approach is the first to provide voxel-wise CSF measurements directly from brain activity, offering insights into spatial frequency tuning across visual areas. NeuroCSF has potential clinical applications for disorders affecting contrast sensitivity and visual field function, such as amblyopia and traumatic brain injury.