Klippel-Trenaunay Syndrome and Cellulitis: Orthopaedic Considerations and Risk Factors – A Case Report

Case: A 41-year-old female with Klippel-Trenaunay Syndrome (KTS) presented with worsening left lower extremity cellulitis and non-healing ulcers. Her medical history included epilepsy and hemiplegic migraines. Physical examination revealed ulcerations, erythema, and vascular malformations. Laboratory tests indicated leukocytosis and systemic inflammation. MRI confirmed vascular malformations and infection. The patient was treated with antibiotics and wound care, leading to improvement in her condition. Conclusion: This case highlights the increased risk of cellulitis in patients with KTS due to vascular malformations and chronic venous insufficiency. It also underscores the importance of early intervention and a multidisciplinary approach to prevent recurrent cellulitis and related complications, such as osteomyelitis.