GAS5 decreased the arecoline-induced myofibroblasts activity in buccal mucosal fibroblasts via acting as a competing endogenous RNA for miR-21
Our findings suggest that GAS5 plays a crucial role in inhibiting myofibroblast activation in OSF by targeting the TGF-β/Smad2 signaling pathway and regulating the miR-21. GAS5 may represent a novel therapeutic target for the prevention and treatment of OSF.
Authors
- Chuan‐Hang Yu (ORCID: https://orcid.org/0000-0002-4535-1176)
- Cheng‐Chia Yu (ORCID: https://orcid.org/0000-0002-2720-3145)
- Jung‐Chun Yeh
- Heng-Yi Liao (ORCID: https://orcid.org/0000-0001-9344-7650)
- Shih‐Min Wang (ORCID: https://orcid.org/0000-0002-4890-5656)
- Yi-Wen Liao
- Fu-Chen Lin
- Ming-Yi Lu
Institutions
- Chung Shan Medical University Hospital (TW)
- Changhua Christian Hospital (TW)
- Chung Shan Medical University (TW)
Publication Details
- Journal
- Journal of Dental Sciences
- Published
- 2025-04-18
- DOI
- https://doi.org/10.1016/j.jds.2025.04.008
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Changhua Christian Hospital
- Chung Shan Medical University Hospital