Cytoprotective Nanoencapsulation of Probiotic Cells within Fe<sup>3+</sup>-Phytic Acid Nanoshells
Probiotic oral delivery is challenged by harsh gastrointestinal conditions and environmental stressors in the body. This study presents the construction of durable nanoshells composed of an Fe<sup>3+</sup>-phytic acid metal-organic complex around individual probiotic cells, providing exceptional cytoprotective properties, in single-cell nanoencapsulation. Nanoencapsulated <i>Levilactobacillus brevis</i> maintains high viability under simulated gastric fluid and the antibiotic tetracycline. The Fe<sup>3+</sup>-phytic acid nanoshells provide an effective platform for improving the viability and functionality of probiotics in therapeutic and nutritional applications.
Authors
- Eunhye Kang
- Seoin Yang
- Duc Tai Nguyen (ORCID: https://orcid.org/0000-0002-8085-2187)
- Insung S. Choi (ORCID: https://orcid.org/0000-0002-9546-673X)
- Beom Jin Kim (ORCID: https://orcid.org/0000-0003-1526-6445)
- Ghanyatma Adi Baskoro
- Nayoung Kim (ORCID: https://orcid.org/0000-0001-6808-8625)
- Sang-Hee Lee (ORCID: https://orcid.org/0000-0003-0069-3831)
- Kyung‐Bok Lee (ORCID: https://orcid.org/0000-0003-1495-3462)
- Sang Yeong Han
Institutions
- Korea Advanced Institute of Science and Technology (KR)
- University of Ulsan (KR)
- Kootenay Association for Science & Technology (CA)
Publication Details
- Journal
- Langmuir
- Published
- 2025-04-18
- DOI
- https://doi.org/10.1021/acs.langmuir.5c00722
- Citations
- 4
- Primary Topic
- Phytase and its Applications
- Type
- article
- Field-Weighted Citation Impact
- 7.00
Funders
- National Research Foundation of Korea