Novel color via stimulation of individual photoreceptors at population scale

We introduce a principle, Oz, for displaying color imagery: directly controlling the human eye's photoreceptor activity via cell-by-cell light delivery. Theoretically, novel colors are possible through bypassing the constraints set by the cone spectral sensitivities and activating M cone cells exclusively. In practice, we confirm a partial expansion of colorspace toward that theoretical ideal. Attempting to activate M cones exclusively is shown to elicit a color beyond the natural human gamut, formally measured with color matching by human subjects. They describe the color as blue-green of unprecedented saturation. Further experiments show that subjects perceive Oz colors in image and video form. The prototype targets laser microdoses to thousands of spectrally classified cones under fixational eye motion. These results are proof-of-principle for programmable control over individual photoreceptors at population scale.

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Publication Details

Journal
Science Advances
Published
2025-04-18
DOI
https://doi.org/10.1126/sciadv.adu1052
Citations
7
Primary Topic
Retinal Development and Disorders
Type
article
Field-Weighted Citation Impact
5.64
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article

Novel color via stimulation of individual photoreceptors at population scale

William S. Tuten, Hannah K. Doyle, Brian P. Schmidt, John E. Vanston et al.
7 citations
Science Advances
Retinal Development and Disorders
5.64
article

Novel color via stimulation of individual photoreceptors at population scale

William S. Tuten, Hannah K. Doyle, Brian P. Schmidt, John E. Vanston, Alexandra E. Boehm, Vimal Prabhu Pandiyan, Congli Wang, James Fong, Ramkumar Sabesan, Austin Roorda, Sofie R. Herbeck, Ren Ng, Pavan Tiruveedhula
article en
7 citations

Abstract

We introduce a principle, Oz, for displaying color imagery: directly controlling the human eye's photoreceptor activity via cell-by-cell light delivery. Theoretically, novel colors are possible through bypassing the constraints set by the cone spectral sensitivities and activating M cone cells exclusively. In practice, we confirm a partial expansion of colorspace toward that theoretical ideal. Attempting to activate M cones exclusively is shown to elicit a color beyond the natural human gamut, formally measured with color matching by human subjects. They describe the color as blue-green of unprecedented saturation. Further experiments show that subjects perceive Oz colors in image and video form. The prototype targets laser microdoses to thousands of spectrally classified cones under fixational eye motion. These results are proof-of-principle for programmable control over individual photoreceptors at population scale.

Science AdvancesVol. 11(16)
University of Washington (US), University of California, Berkeley (US)
Openalex Percentile: Top 4%
Retinal Development and Disorders
5.64
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Novel color via stimulation of individual photoreceptors at population scale — William S. Tuten, Hannah K. Doyle, et al. · Science Advances (2025) | TGRS Research Map | TGRS