N-glycan-modified α-L-iduronidase produced by transgenic silkworms ameliorates clinical signs in a Japanese macaque with mucopolysaccharidosis I
These glycotechnologies using transgenic silkworms and ENGases are expected to serve as platforms for developing therapeutic glycoproteins.
Authors
- Chika Shinoda
- Tetsuya Iizuka (ORCID: https://orcid.org/0000-0002-1512-4714)
- Keisuke Kitakaze (ORCID: https://orcid.org/0000-0002-4852-1257)
- Takao Oishi (ORCID: https://orcid.org/0000-0003-1067-3746)
- So-ichiro Nishioka
- Isao Kobayashi (ORCID: https://orcid.org/0000-0001-9062-5554)
- Satomi Nadanaka (ORCID: https://orcid.org/0000-0001-7650-836X)
- Jun Tsukimoto (ORCID: https://orcid.org/0000-0002-2769-1505)
- Megumi Sumitani (ORCID: https://orcid.org/0000-0001-6072-9600)
- Takashi Kinoshita (ORCID: https://orcid.org/0000-0002-3468-002X)
- Akiko Ishii‐Watabe (ORCID: https://orcid.org/0000-0003-2167-2263)
- Akira Harazono (ORCID: https://orcid.org/0000-0002-0307-7404)
- Akihiro Hirata (ORCID: https://orcid.org/0000-0003-2268-504X)
- Yasuhiro Go (ORCID: https://orcid.org/0000-0003-4581-0325)
- Ai Mitani
- Kohji Itoh
- Hideki Sezutsu (ORCID: https://orcid.org/0000-0001-8886-1611)
- Yasuyuki Suzuki (ORCID: https://orcid.org/0000-0002-4871-9685)
- Akihisa Kaneko
- Takako Miyabe‐Nishiwaki (ORCID: https://orcid.org/0000-0001-6502-655X)
- Kei Kiriyama
- Hiroshi Kitagawa (ORCID: https://orcid.org/0000-0002-9307-7079)
- Teru Mizuno
- Yoshie Takeuchi
- Yuya Sasai
- Masanori Imamura
- Ken‐ichiro Tatematsu
Institutions
- Kanazawa University (JP)
- National Agriculture and Food Research Organization (JP)
- Kanazawa Medical University (JP)
- University of Hyogo (JP)
- Kawasaki Medical School (JP)
- Kobe Pharmaceutical University (JP)
- National Institutes of Natural Sciences (JP)
- Kyoto University (JP)
- Institute of Agrobiological Sciences (JP)
- KRI (JP)
- Maruishi Pharmaceutical (Japan) (JP)
- Institut de Biologia Evolutiva (ES)
- National Institute of Health Sciences (JP)
- Gifu University (JP)
- Tokushima University (JP)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-04-18
- DOI
- https://doi.org/10.1038/s43856-025-00841-7
- Citations
- 2
- Primary Topic
- Lysosomal Storage Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- Mizutani Foundation for Glycoscience
- Japan Agency for Medical Research and Development
- Ministry of Agriculture, Forestry and Fisheries
- Japan Society for the Promotion of Science
- Japan Science and Technology Agency