HLA-F regulates the proliferation of trophoblast via PKM2-dependent glycolysis in the pathogenesis of preeclampsia
The reduced expression of HLA-F in placental trophoblast cells resulted in the downregulation of both PKM2 transcription and protein expression. Concurrently, the relative upregulation of lactylation at PKM2 K305 contributed to a decline in enzyme activity, further exacerbating glycolysis dysfunction. Collectively, these alterations led to a suppression of trophoblast proliferation capacity and involvement in the pathogenesis of preeclampsia.
Authors
- Fulin Liu (ORCID: https://orcid.org/0000-0002-0072-0847)
- Ruiling Xu (ORCID: https://orcid.org/0000-0002-7205-0459)
- Jie Mei (ORCID: https://orcid.org/0000-0002-5182-5059)
- Fangyuan Luo (ORCID: https://orcid.org/0000-0001-6449-0705)
- Dan Luo (ORCID: https://orcid.org/0000-0001-6074-1298)
- Xinghui Liu (ORCID: https://orcid.org/0000-0001-7366-0825)
- Yu Huang (ORCID: https://orcid.org/0000-0003-0433-9493)
- Wenchi Xie (ORCID: https://orcid.org/0009-0007-1180-6607)
Institutions
- Affiliated Hospital of Southwest Medical University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-04-18
- DOI
- https://doi.org/10.1186/s10020-025-01201-w
- Citations
- 6
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 12.34