Synergistic Inhibition of Nav1.7 and <scp>NCX</scp> 1: A Novel Strategy for Treating Cancer‐Induced Bone Pain by Modulating Pain Sensitization and Neuronal Inflammation
The combined inhibition of Nav1.7 and NCX1 enhances analgesic effects and reduces neuroinflammation, presenting a potential therapeutic approach for CIBP and other cancer-associated pain disorders.
Authors
- Xiangnan Chen (ORCID: https://orcid.org/0000-0002-6744-3418)
- Peizong Wang
- Dongtai Chen (ORCID: https://orcid.org/0000-0003-0193-2902)
- Qiang Li (ORCID: https://orcid.org/0000-0002-5289-0709)
- Wei Xing (ORCID: https://orcid.org/0000-0002-9042-0281)
- Weian Zeng (ORCID: https://orcid.org/0000-0002-6783-2245)
- Yan Yan (ORCID: https://orcid.org/0000-0001-9945-3509)
- Yang Huang (ORCID: https://orcid.org/0000-0003-3734-5515)
- Yan Fang (ORCID: https://orcid.org/0000-0001-5765-1240)
- Yan Feng
Institutions
- Sun Yat-sen University (CN)
- Huizhou Central People's Hospital (CN)
- Guangdong Province Women and Children Hospital (CN)
- Sun Yat-sen University Cancer Center (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1111/cns.70389
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province