A novel microfluidic method to produce monodisperse micrometer bubbles

We present a novel microfluidic method to produce quasi-monodisperse bubbles with diameters from tens to very few microns. A gaseous rivulet flows over the shallow groove printed on a T-junction exit channel. The triple contact line delimiting the rivulet is pinned to the groove edges. The rivulet breaks up into bubbles much smaller than the exit channel. When operating under adequate conditions, the flow transitions toward a singular mode where the rivulet remains quasi-static and emits bubbles smaller than the groove width. This allows the production of bubbles with diameters in the 3- 5 μ m range, which is preferable for relevant therapeutical applications. • We present a microfluidic method to produce quasi-monodisperse micro-bubbles. • Flow focusing is produced in a T-junction with a groove printed on its surface. • The bubble diameter can be reduced to 3 microns. • The produced bubbles are suitable for therapeutical applications.