Regional Differences in the Frequency of <scp><i>BRCA1</i></scp> and <scp><i>BRCA2</i></scp> Variants in Northeastern Japan: A Cohort Study
These results highlight the importance of considering regional differences in comparative cohort studies, particularly in assessing the differential extension of mutations in pathogenic changes and VUS. Moreover, a presumption of pathogenicity variants would need to be discussed at the regional level.
Authors
- Chikashi Ishioka (ORCID: https://orcid.org/0000-0002-3023-1227)
- Muneaki Shimada (ORCID: https://orcid.org/0000-0003-1826-6723)
- Tetsuya Niihori (ORCID: https://orcid.org/0000-0002-2118-9776)
- Maako Kawamura
- Tomoyuki Iwasaki (ORCID: https://orcid.org/0000-0002-1000-2099)
- Toru Furukawa (ORCID: https://orcid.org/0000-0002-1083-2324)
- Eisaku Miyauchi (ORCID: https://orcid.org/0000-0002-6837-6392)
- K Saito
- Shuhei Suzuki (ORCID: https://orcid.org/0009-0003-8108-3230)
- Keigo Komine (ORCID: https://orcid.org/0000-0003-2502-3666)
- Hidetaka Niizuma (ORCID: https://orcid.org/0000-0002-3161-8968)
- Naoki Kawamorita (ORCID: https://orcid.org/0000-0001-6175-3063)
- Ken Saijo (ORCID: https://orcid.org/0000-0003-0179-3789)
- Masanobu Takahashi
- Jun Yasuda (ORCID: https://orcid.org/0000-0002-3887-6871)
- Masayuki Kanamori (ORCID: https://orcid.org/0000-0002-3380-1192)
- Hidekazu Shirota (ORCID: https://orcid.org/0000-0001-9154-9004)
- Yoko Aoki (ORCID: https://orcid.org/0000-0002-1194-6972)
- Gen Tamiya (ORCID: https://orcid.org/0000-0002-0597-415X)
- Akimitsu Miyake (ORCID: https://orcid.org/0000-0001-8509-1412)
- Yuki Kasahara
- Hiroshi Tada (ORCID: https://orcid.org/0000-0003-2670-8982)
- Motonobu Saito (ORCID: https://orcid.org/0000-0001-5072-3520)
- Takeshi Iwaya (ORCID: https://orcid.org/0000-0001-8341-5700)
- Hiroo Imai (ORCID: https://orcid.org/0000-0002-1319-724X)
- Hiroyuki Shibata (ORCID: https://orcid.org/0000-0003-3581-3506)
Institutions
- Yamagata University (JP)
- Fukushima Medical University (JP)
- Hirosaki University (JP)
- Iwate Medical University (JP)
- Tohoku University (JP)
- Akita University (JP)
- Tohoku University Hospital (JP)
- Miyagi Prefectural Hospital Organization (JP)
- Tohoku Medical Megabank Organization (JP)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/cam4.70443
- Citations
- 2
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.63