Localization of E-cadherin and Vimentin in Mucosal Ulcer Healing Treated by Vitis Vinifera Seeds Oil in Rat Model

Objective: The anti-inflammatory components generated by Vitis vinifera (Grape) seeds oil (GSO) help reduce inflammation and accelerate the healing process when applied topically to an ulcer. The current study aimed to assess the expression of E-cadherin and Vimentin during oral ulcer healing treated by GSO. Materials and Methods: Twenty-four albino male rats (350–450 g) were used for this study. The rats were slaughtered on the 5th and 10th days after an ulcer induction on either their left or right cheek mucosa. The rats in the control group received sterile distilled water, whereas those in the experimental group received GSO for ulcers treatment. The tissue samples were subsequently utilized for histological and immunohistochemical investigations of E-cadherin and Vimentin. Results: Compared with the control group, the GSO-treated ulcer group presented significantly higher expression of E-cadherin and Vimentin at days 5 and 10 than the control group, with some evidence of epithelial-mesenchymal transition (EMT) at 5 days in both groups. Conclusion: With the limitation of this study, GS may accelerate the healing of mucosal ulcers, as demonstrated by increased expression of E-cadherin and Vimentin. Clinical relevance: GSO can be used as a topical herbal modality for mucosal ulcer healing.