Inhibition of ceramide synthesis improves the outcome of ischemia/reperfusion injury in cardiomyocytes derived from human induced pluripotent stem cell
Results from both in vitro and in vivo experiments show that ceramides have a significant role in either mediating or inducing damage to CMs. Additionally, in vitro findings show that ceramide reduction improves the outcome of IR injury by lowering intracellular Ca<sup>2+</sup> [Ca<sup>2+</sup>]<sub>i</sub> concentration and improves mitochondrial function changes during IR.
Authors
- Paul Christian Schulze (ORCID: https://orcid.org/0000-0001-9442-7141)
- Tom Kretzschmar (ORCID: https://orcid.org/0000-0002-5296-3955)
- Mohamed M. Bekhite (ORCID: https://orcid.org/0000-0003-0346-9181)
- Claudia Backsch (ORCID: https://orcid.org/0000-0003-1679-6464)
- Elisabeth Klein
- Markus H. Gräler (ORCID: https://orcid.org/0000-0001-6650-7849)
- Sascha Hübner
- Jasmine Wu (ORCID: https://orcid.org/0000-0002-4072-7170)
- Tina Müller (ORCID: https://orcid.org/0000-0002-7612-139X)
- Anja Weise (ORCID: https://orcid.org/0000-0003-3988-8919)
- P Haxhikadrija
- Katja Grün (ORCID: https://orcid.org/0000-0001-7859-5444)
Institutions
- Jena University Hospital (DE)
- Friedrich Schiller University Jena (DE)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-04-18
- DOI
- https://doi.org/10.1186/s13287-025-04340-3
- Citations
- 4
- Primary Topic
- Zebrafish Biomedical Research Applications
- Type
- article
- Field-Weighted Citation Impact
- 4.61
Funders
- Universitätsklinikum Jena