Generation and purification of iPSC-derived cardiomyocytes for clinical applications

We describe the generation and further processing of xeno- and transgene-free iCMs. The use of GMP-compliant differentiation protocols ab initio facilitates the clinical translation of this project in later stages.

Authors

Melanie Generali (ORCID: https://orcid.org/0000-0001-8396-3256)
Hirohide Saito (ORCID: https://orcid.org/0000-0002-8570-5784)
Kirstin Atrott
Debora Kehl
Dankwart Meier
MY Emmert
SP Hoerstrup
Dennis Zorndt

Institutions

University of Zurich (CH)
Kyoto University (JP)
ETH Zurich (CH)
University Hospital of Zurich (CH)
Deutsches Herzzentrum der Charité (DE)
The University of Tokyo (JP)
Charité - Universitätsmedizin Berlin (DE)

Publication Details

Journal: Stem Cell Research & Therapy
Published: 2025-04-18
DOI: https://doi.org/10.1186/s13287-025-04319-0
Citations: 4
Primary Topic: Pluripotent Stem Cells Research
Type: article
Field-Weighted Citation Impact: 3.22

Funders

Mäxi-Stiftung

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article

Generation and purification of iPSC-derived cardiomyocytes for clinical applications

Melanie Generali, Hirohide Saito, Kirstin Atrott, Debora Kehl et al.

Apr 18, 2025

4 citations

Stem Cell Research & Therapy

Pluripotent Stem Cells Research

3.22

article

Generation and purification of iPSC-derived cardiomyocytes for clinical applications

Melanie Generali, Hirohide Saito, Kirstin Atrott, Debora Kehl, Dankwart Meier, MY Emmert, SP Hoerstrup, Dennis Zorndt

April 18, 2025article en

4 citations

Abstract

We describe the generation and further processing of xeno- and transgene-free iCMs. The use of GMP-compliant differentiation protocols ab initio facilitates the clinical translation of this project in later stages.

Stem Cell Research & TherapyVol. 16(1)

University of Zurich (CH), Kyoto University (JP), ETH Zurich (CH), University Hospital of Zurich (CH), Deutsches Herzzentrum der Charité (DE), The University of Tokyo (JP), Charité - Universitätsmedizin Berlin (DE)

Mäxi-Stiftung

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Openalex Percentile: Top 9%

Pluripotent Stem Cells Research

3.22

DOI Open Access PDF OpenAlex

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Generation and purification of iPSC-derived cardiomyocytes for clinical applications — Melanie Generali, Hirohide Saito, et al. · Stem Cell Research & Therapy (2025) | TGRS Research Map | TGRS