Extracellular vesicles from hiPSC-derived NSCs protect human neurons against Aβ-42 oligomers induced neurodegeneration, mitochondrial dysfunction and tau phosphorylation
An optimal dose of hiPSC-NSC-EVs could significantly decrease the degeneration of human neurons induced by Aβ-42o. The results support further research into the effectiveness of hiPSC-NSC-EVs in AD, particularly their proficiency in preserving neurons and slowing disease progression.
Authors
- Roshni Sara Babu
- Goutham Shankar
- James J. Cai (ORCID: https://orcid.org/0000-0002-8081-6725)
- Ashok K. Shetty
- Shama Rao
- Esha Narvekar
- Raghavendra Upadhya
- Leelavathi N. Madhu
- Sanya Kotian
- Advaidhaa Nagarajan
Institutions
- Texas A&M Health Science Center (US)
- Texas A&M University (US)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-04-18
- DOI
- https://doi.org/10.1186/s13287-025-04324-3
- Citations
- 9
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 10.48
Funders
- National Science Council
- National Institute on Aging