The role of PKM2-mediated metabolic reprogramming in the osteogenic differentiation of BMSCs under diabetic periodontitis conditions
PKM2 impairs the osteogenesis of BMSCs by affecting metabolism and mitochondrial function, suggesting it as a potential therapeutic target for diabetic periodontitis.
Authors
- Yanlin Zhu (ORCID: https://orcid.org/0000-0003-0044-9433)
- Xiang Gao (ORCID: https://orcid.org/0000-0003-2617-6509)
- Yuyan Lan
- Jie Zhou (ORCID: https://orcid.org/0000-0001-5359-9246)
- Yuhan Yang (ORCID: https://orcid.org/0000-0002-4177-6396)
- Zun Yang
Institutions
- Chongqing University (CN)
- Stomatological Hospital of Chongqing Medical University (CN)
- Chongqing Municipal Government (CN)
- First People's Hospital of Chongqing (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-04-18
- DOI
- https://doi.org/10.1186/s13287-025-04301-w
- Citations
- 8
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 7.49
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Chongqing