The State of The Prostacyclin-Thromboxane System in Patients with Acute Circulatory Disorders in The Early Postoperative Period After Aorto-Coronary Bypass Surgery

In order to clarify the role of the prostacyclin-thromboxane system (PTS) in the development of acute circulatory disorders in the early postoperative period after coronary artery bypass surgery. Its condition was studied in 86 patients with coronary artery disease. In patients with the development of vascular insufficiency and shock, a decrease in the level of thromboxane in the blood was revealed, while in patients with arterial hypertension, elevated concentrations of thromboxane in the blood were determined in the absence of changes in the level of prostacyclin. There were no significant differences in the content of prostacyclin and thromboxane between groups of patients with uncomplicated postoperative course and with the development of such complications as heart failure and hypovolemia. It has been established that the factors influencing the state of PTS in patients after coronary artery bypass grafting (CABG) are: the duration of cardiopulmonary bypass, blood loss during surgery, the number of platelets in the blood, hypocapnia. The factors influencing the aggregation ability of platelets are: the duration of cardiopulmonary bypass, the number of platelets, the degree of “emptying” of platelet alpha granules of platelets, the functional state of PTS.