Sex differences in myocardial flow reserve among individuals with type 2 diabetes: insights from the DiaHeart study
In individuals with type 2 diabetes without overt CVD, women exhibited lower MFR than men, primarily due to higher MBF at rest, suggesting sex-related differences. While MFR declined in both sexes, the sex difference was more pronounced in younger individuals and diminished over time. These findings underscore the need for further research into sex-specific thresholds for MFR in cardiovascular risk stratification.
Authors
- Lene Holmvang (ORCID: https://orcid.org/0000-0002-0941-378X)
- Tine W. Hansen (ORCID: https://orcid.org/0000-0003-2274-0352)
- Philip Hasbak (ORCID: https://orcid.org/0000-0002-6254-6012)
- Emilie H. Zobel (ORCID: https://orcid.org/0000-0003-3318-7070)
- Mats Christian Højbjerg Lassen (ORCID: https://orcid.org/0000-0002-2255-582X)
- Allan Kofoed‐Enevoldsen (ORCID: https://orcid.org/0000-0001-7051-1381)
- Andreas Kjær (ORCID: https://orcid.org/0000-0002-2706-5547)
- Urd Kielgast (ORCID: https://orcid.org/0000-0001-9914-0676)
- Ida Kirstine Bull Rasmussen (ORCID: https://orcid.org/0000-0001-6849-763X)
- R Ripa (ORCID: https://orcid.org/0000-0003-2035-2321)
- Morten Lindhardt (ORCID: https://orcid.org/0000-0001-6063-1718)
- Tor Biering‐Sørensen (ORCID: https://orcid.org/0000-0003-4209-2778)
- Jens P. Goetze (ORCID: https://orcid.org/0000-0001-6356-3829)
- Peter R Rossing (ORCID: https://orcid.org/0000-0002-1531-4294)
- Victor Wasehuus (ORCID: https://orcid.org/0000-0003-1822-8188)
- Anne-Cathrine Skriver-Møller
- Martin Bæk Blond (ORCID: https://orcid.org/0000-0002-2032-1560)
Institutions
- University of Copenhagen (DK)
- Steno Diabetes Centers (DK)
- Copenhagen University Hospital (DK)
- Gentofte Hospital (DK)
- Rigshospitalet (DK)
- Zealand University Hospital (DK)
- Holbæk Sygehus (DK)
- Zealand University Hospital Køge (DK)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-04-18
- DOI
- https://doi.org/10.1186/s12933-025-02717-5
- Citations
- 4
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 5.55
Funders
- Steno Diabetes Center Copenhagen
- Københavns Universitet
- Novo Nordisk
- Rigshospitalet
- Novo Nordisk Fonden