Enhanced intracranial aneurysm development in a rat model of polycystic kidney disease
Our study showed that PCK rats are more sensitive to IA induction. Variations in the anatomy of the circle of Willis and impaired regulation of tight junction proteins might put PCK rats and PKD patients more at risk of developing vulnerable IAs.
Authors
- Anne F. Cayron (ORCID: https://orcid.org/0000-0002-9408-7295)
- Éric Allémann (ORCID: https://orcid.org/0000-0002-6598-9521)
- Julien Haemmerli (ORCID: https://orcid.org/0000-0001-5998-8541)
- Sandrine Morel (ORCID: https://orcid.org/0000-0003-1538-3553)
- Philippe Bijlenga (ORCID: https://orcid.org/0000-0002-3586-2757)
- Tomohiro Aoki (ORCID: https://orcid.org/0000-0002-1578-1394)
- Brenda R. Kwak (ORCID: https://orcid.org/0000-0003-0015-0044)
- Maral Azam
Institutions
- University of Geneva (CH)
- Jikei University School of Medicine (JP)
- Centre de Recherche sur l'Inflammation (FR)
- Geneva College (US)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1093/cvr/cvaf063
- Citations
- 2
- Primary Topic
- Genetic and Kidney Cyst Diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.63
Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Schweizerische Herzstiftung
- Gottfried und Julia Bangerter-Rhyner-Stiftung
- Hôpitaux Universitaires de Genève