Standardization Study and Anti-inflammatory Effect of Erkhem-8 Herbal Tablet

Erkhem-8 herbal tablet, named BTSO BO BRGYAD in Tibetan, is prescribed for all types of fever, especially typhus and contagious fever in Mongolian traditional medicine. In the current study, the purpose was to establish the requirements of the standard on the medicine in tablet form and the febrifugal effect of the Erkhem-8 herbal tablet. 712 mg/kg of Erkhem-8 tablet decreased the temperature of the rectum in 1 h-4 h compared to the lipopolysaccharide model group (p <0.01). The temperature of the rectum of animals in the comparative group was statistically significantly reduced at 2 h and 6 h compared to the healthy rats (p<0.01). The group of Erkhem-8 tablet+lipopolysaccharide decreased the interleukin-1beta cytokines level up to 33.5 % (p=0.05) from the group that treated lipopolysaccharide and the concentration of the interleukin-6 cytokines in the treatment group was statistically significantly reduced by 17.77±2.6 pg/ml or 27.5 % (p=0.05). A slight thickening of the alveolar walls, less blood stasis, and less fluid in the alveolar air spaces were detected in the Erkhem-8 tablet+lipopolysaccharide group. Overall, the criteria of the standardization parameter for the Erkhem-8 herbal tablet were established and the febrifugal effect of the tablet was evaluated. Key words: Traditional medicine, febrifugal effect, fever, inflammation, apigenin, luteolin