An Investigation of Corticospinal Tract Microstructural Integrity in ARSACS Using a Profilometry MRI Analysis: Results From the PROSPAX Study
A clinically meaningful microstructural involvement of CST is present in ARSACS patients, with a spatially defined pattern of damage occurring right below and above a thickened pons. An evaluation of the microstructure of this bundle might serve as a possible biomarker in this condition.
Authors
- Roberta La Piana (ORCID: https://orcid.org/0000-0002-4207-5065)
- Mirco Cosottini (ORCID: https://orcid.org/0000-0001-9400-6574)
- Sara Bosticardo (ORCID: https://orcid.org/0000-0002-0063-2521)
- Matthis Synofzik (ORCID: https://orcid.org/0000-0002-2280-7273)
- Alessandro Daducci (ORCID: https://orcid.org/0000-0002-4677-6678)
- Ilaria Gabusi (ORCID: https://orcid.org/0000-0002-2553-8304)
- Benjamin Bender (ORCID: https://orcid.org/0000-0002-3205-4631)
- Christoph Keßler (ORCID: https://orcid.org/0000-0001-6211-903X)
- Dagmar Timmann (ORCID: https://orcid.org/0000-0003-1935-416X)
- Filippo Maria Santorelli (ORCID: https://orcid.org/0000-0002-1359-9062)
- Sirio Cocozza (ORCID: https://orcid.org/0000-0002-0300-5160)
- Alessandra Scaravilli (ORCID: https://orcid.org/0000-0001-6375-5783)
- Simona Schiavi (ORCID: https://orcid.org/0000-0003-1641-186X)
- Matteo Battocchio
- Rebecca Schüle (ORCID: https://orcid.org/0000-0002-7781-2766)
- Gaia Mari
- Bart P. van de Warrenburg
Institutions
- University of Pisa (IT)
- University of Verona (IT)
- Montreal Neurological Institute and Hospital (CA)
- Radboud University Nijmegen (NL)
- Heidelberg University (DE)
- German Center for Neurodegenerative Diseases (DE)
- University Hospital Heidelberg (DE)
- Radboud University Medical Center (NL)
- Essen University Hospital (DE)
- Fondazione Stella Maris (IT)
- Hertie Institute for Clinical Brain Research (DE)
- McGill University (CA)
- University of Naples Federico II (IT)
- University of Tübingen (DE)
Publication Details
- Journal
- European Journal of Neurology
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1111/ene.70128
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Fondazione Telethon
- Ministero della Salute