High Agreement Across Laboratories Between Different Alpha‐Synuclein Seed Amplification Protocols
The qualitative SAA results showed a high level of agreement across research laboratories, aSYN monomers, and assay protocols. Small differences between laboratories were systematic, consistent with the notion that SAA reports biologically relevant properties. These results also underline that round-robin tests can be helpful in assessing and ensuring SAA quality across laboratories.
Authors
- Kinsolving Julia
- Vaibhavi Kadam
- Kathrin Brockmann (ORCID: https://orcid.org/0000-0002-7515-8596)
- Karin M. Danzer (ORCID: https://orcid.org/0000-0003-0133-7046)
- Piero Parchi (ORCID: https://orcid.org/0000-0002-9444-9524)
- Sandra Kuhs (ORCID: https://orcid.org/0000-0003-0464-7031)
- Stefan Bräuer (ORCID: https://orcid.org/0000-0003-2449-5530)
- Matthis Synofzik (ORCID: https://orcid.org/0000-0002-2280-7273)
- A. Bernhardt (ORCID: https://orcid.org/0000-0001-9974-8091)
- Johannes Levin (ORCID: https://orcid.org/0000-0001-5092-4306)
- Luis Concha‐Marambio (ORCID: https://orcid.org/0000-0002-9454-8389)
- Iñaki Schniewind (ORCID: https://orcid.org/0000-0003-4546-1479)
- David Mengel (ORCID: https://orcid.org/0000-0002-4133-7182)
- Marcello Rossi (ORCID: https://orcid.org/0000-0002-8125-6571)
- Björn Falkenburger (ORCID: https://orcid.org/0000-0002-2387-526X)
- Maximilian Weber (ORCID: https://orcid.org/0000-0002-3337-1495)
- Christian Deuschle (ORCID: https://orcid.org/0000-0001-5571-7293)
- Wolfgang Ruf (ORCID: https://orcid.org/0000-0002-8105-6123)
- Jan Kassubek (ORCID: https://orcid.org/0000-0002-7106-9270)
Institutions
- Universität Ulm (DE)
- German Center for Neurodegenerative Diseases (DE)
- Munich Cluster for Systems Neurology (DE)
- Amprion (United States) (US)
- Istituto delle Scienze Neurologiche di Bologna (IT)
- Hertie Institute for Clinical Brain Research (DE)
- Technische Universität Dresden (DE)
- University of Tübingen (DE)
- Ludwig-Maximilians-Universität München (DE)
- University of Bologna (IT)
Publication Details
- Journal
- European Journal of Neurology
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1111/ene.70165
- Citations
- 8
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 11.11
Funders
- Else Kröner-Fresenius-Stiftung
- Deutsches Zentrum für Neurodegenerative Erkrankungen