Psilocybin and ketamine affect novel neuropeptides gene expression in the rat hypothalamus
These results suggest for the first time that selected psychedelics may enhance the signaling of 5-HT2A receptors or inhibit NMDA receptor activity, affecting neuropeptide signaling and serotonin transmission in the rat hypothalamus, which may contribute to a better understanding of psychedelic action in the brain.
Authors
- Artur Pałasz (ORCID: https://orcid.org/0000-0002-2632-1211)
- John J. Worthington (ORCID: https://orcid.org/0000-0002-1429-5669)
- Katarzyna Bogus (ORCID: https://orcid.org/0000-0001-7476-6445)
- Agnieszka Bysiek
- Krystyna Gołembiowska (ORCID: https://orcid.org/0000-0002-5018-1394)
- Aleksandra Suszka‐Świtek (ORCID: https://orcid.org/0000-0002-4176-7035)
- Adam Wojtas (ORCID: https://orcid.org/0000-0001-7785-8396)
- Kinga Mordecka‐Chamera (ORCID: https://orcid.org/0000-0003-1806-7716)
- Łukasz Filipczyk (ORCID: https://orcid.org/0000-0001-9352-0715)
- Marta Pukowiec
- Maria Sygidus
Institutions
- Medical University of Silesia (PL)
- Maj Institute of Pharmacology (PL)
- Lancaster University (GB)
- Polish Academy of Sciences (PL)
Publication Details
- Journal
- Journal of Psychopharmacology
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1177/02698811251330783
- Primary Topic
- Psychedelics and Drug Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Śląski Uniwersytet Medyczny