X-Linked Hypophosphatemia Management in Adults: An International Working Group Clinical Practice Guideline
In adults with XLH and fractures or pseudofractures, burosumab is recommended over no therapy (strong recommendation, GRADEd). Additionally, burosumab is suggested as the preferred treatment compared to conventional therapy (conditional recommendation, GRADEd) in the absence of fractures or pseudofractures. If burosumab is not available, symptomatic adults should be treated with conventional therapy (Non-GRADEd recommendation).
Authors
- Paul Goodyer (ORCID: https://orcid.org/0000-0002-3442-1407)
- Suzanne M. Jan de Beur (ORCID: https://orcid.org/0000-0002-9386-7732)
- Seiji Fukumoto (ORCID: https://orcid.org/0000-0003-3610-3469)
- Pablo F Florenzano (ORCID: https://orcid.org/0000-0001-5936-3146)
- Thomas O. Carpenter (ORCID: https://orcid.org/0000-0003-1328-6768)
- Erik Allen Imel (ORCID: https://orcid.org/0000-0002-7284-3467)
- Rachel Crowley (ORCID: https://orcid.org/0000-0003-1472-4117)
- Karel Dandurand (ORCID: https://orcid.org/0000-0003-1759-8419)
- Lisa Friedlander (ORCID: https://orcid.org/0000-0003-3056-3624)
- Anthony A. Portale (ORCID: https://orcid.org/0000-0003-2054-6898)
- Robert Todd Alexander (ORCID: https://orcid.org/0000-0001-7396-7894)
- Martin Biosse Duplan (ORCID: https://orcid.org/0000-0001-9417-3970)
- Heide Siggelkow (ORCID: https://orcid.org/0000-0002-8366-8625)
- Gordon Guyatt (ORCID: https://orcid.org/0000-0003-2352-5718)
- Signe Sparre Beck‐Nielsen (ORCID: https://orcid.org/0000-0002-7561-9217)
- Dalal S. Ali (ORCID: https://orcid.org/0000-0002-5378-5548)
- Catherine Chaussain (ORCID: https://orcid.org/0000-0002-3463-3936)
- Corinna Grasemann (ORCID: https://orcid.org/0000-0003-1793-4603)
- E. Michael Lewiecki (ORCID: https://orcid.org/0000-0003-2026-9587)
- Anna Lehman (ORCID: https://orcid.org/0000-0003-0636-123X)
- Aneal Khan (ORCID: https://orcid.org/0000-0001-8131-7947)
- Guido Filler (ORCID: https://orcid.org/0000-0003-1891-6765)
- Emmett Morgante (ORCID: https://orcid.org/0009-0009-9271-0379)
- Natasha M. Appelman‐Dijkstra (ORCID: https://orcid.org/0000-0001-5035-127X)
- Eric T. Rush (ORCID: https://orcid.org/0000-0002-8147-7315)
- Martine Cohen‐Solal (ORCID: https://orcid.org/0000-0002-8582-8258)
- Sotirios Tetradis (ORCID: https://orcid.org/0000-0002-0157-1855)
- Maria Luisa Brandi (ORCID: https://orcid.org/0000-0002-8741-0592)
- Laura L. Tosi (ORCID: https://orcid.org/0000-0001-8827-9883)
- Farah Alsarraf (ORCID: https://orcid.org/0000-0001-9426-9702)
- Aliya Khan (ORCID: https://orcid.org/0000-0003-3733-8956)
- Yumie Rhee (ORCID: https://orcid.org/0000-0003-4227-5638)
- M K Javaid (ORCID: https://orcid.org/0000-0001-7985-0048)
- Hajar Abu Alrob (ORCID: https://orcid.org/0000-0001-7830-3237)
- Chelsey Grimbly (ORCID: https://orcid.org/0000-0002-9302-7741)
- Leanne Marie Ward (ORCID: https://orcid.org/0000-0003-1557-9185)
- Archibald Morrison
- Willem F. Lems (ORCID: https://orcid.org/0000-0002-6885-3953)
- Reza Mirza (ORCID: https://orcid.org/0000-0002-0576-4208)
- Ciara McDonnell (ORCID: https://orcid.org/0000-0001-9414-5873)
- Claudia Gagnon (ORCID: https://orcid.org/0000-0001-9623-962X)
- Sarah Khan (ORCID: https://orcid.org/0000-0003-3604-303X)
- Salma Hussein (ORCID: https://orcid.org/0000-0002-7284-4822)
- Rana Aldabagh
Institutions
- University College Dublin (IE)
- Children's Mercy Hospital (US)
- Université de Sherbrooke (CA)
- University of British Columbia (CA)
- University of Waterloo (CA)
- University of Ottawa (CA)
- Vita-Salute San Raffaele University (IT)
- University of Alberta (CA)
- Inserm (FR)
- Pontificia Universidad Católica de Chile (CL)
- University of California, San Francisco (US)
- University of Toronto (CA)
- George Washington University (US)
- Yonsei University (KR)
- Aarhus University (DK)
- Université Paris Cité (FR)
- Trinity College Dublin (IE)
- Children's Hospital of Eastern Ontario (CA)
- Leiden University Medical Center (NL)
- Trillium Health Centre (CA)
- London Health Sciences Centre (CA)
- McGill University Health Centre (CA)
- Nuffield Orthopaedic Centre (GB)
- Aarhus University Hospital (DK)
- University Medical Center (US)
- Children's Health Ireland at Crumlin (IE)
- Yale University (US)
- University of Oxford (GB)
- New Mexico Clinical Research & Osteoporosis Center (US)
- Hôpital Lariboisière (FR)
- Women and Children’s Health Research Institute (CA)
- Children's Hospital of Western Ontario (CA)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Katholisches Klinikum Bochum (DE)
- Endokrinologikum (DE)
- Tokushima Hospital (JP)
- Impact (CA)
- Institut des Maladies Génétiques Imagine (FR)
- Université Laval (CA)
- Indiana University School of Medicine
- University of Virginia (US)
- Indiana University – Purdue University Indianapolis (US)
- University of Missouri–Kansas City (US)
- Ruhr University Bochum (DE)
- Citadel (US)
- McMaster University (CA)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1210/clinem/dgaf170
- Citations
- 9
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 12.88
Funders
- McMaster University