Distribution of Intranasally Administered rIL‐10 Along the Olfactory Nerve and Perivascular Space After Intracerebral Hemorrhage
Our findings demonstrate that rIL-10 can permeate the blood-brain barrier and reach the perihematomal area in the striatum of mice with intracerebral hemorrhage. Intranasally administered rIL-10 primarily targets the cerebral cortex, striatum, and thalamus, traversing the olfactory nerve pathway and perivascular space to access these brain regions. This mode of delivery effectively mitigated secondary brain injury after intracerebral hemorrhage. This study contributes to intranasal drug delivery research, offering compelling evidence to support the intranasal delivery of anti-inflammatory cytokines or alternative drug candidates for treating brain diseases.
Authors
- Nan Li (ORCID: https://orcid.org/0000-0002-5070-153X)
- Bing Jiang (ORCID: https://orcid.org/0000-0001-5389-3293)
- Chao Jiang (ORCID: https://orcid.org/0000-0001-5588-4294)
- Ruoqi Ding
- Xinru Zhang (ORCID: https://orcid.org/0009-0009-7625-4537)
- Shijun Xu (ORCID: https://orcid.org/0000-0002-7454-0873)
- Shuaibing Zhang
- Shaoshuai Wang (ORCID: https://orcid.org/0000-0003-0315-7866)
- Xiaochong Fan (ORCID: https://orcid.org/0000-0002-6640-2665)
- Yousef Rastegar‐Kashkooli (ORCID: https://orcid.org/0009-0007-5321-5653)
- Yifei Li (ORCID: https://orcid.org/0009-0009-1059-9268)
- Jian Wang (ORCID: https://orcid.org/0000-0003-2291-640X)
- Xuemei Chen (ORCID: https://orcid.org/0000-0001-5614-6859)
- Shuyu Wang (ORCID: https://orcid.org/0000-0002-6455-5457)
- Junmin Wang (ORCID: https://orcid.org/0000-0003-1823-5388)
- Junyang Wang (ORCID: https://orcid.org/0000-0001-6588-6947)
- Na Xing (ORCID: https://orcid.org/0000-0003-2712-3222)
- Menglu Wang (ORCID: https://orcid.org/0000-0003-3287-2164)
- Siyuan Hu
- Qinfeng Peng
Institutions
- Army Medical University (CN)
- Zhengzhou University (CN)
- Henan Academy of Sciences (CN)
- Second Affiliated Hospital of Zhengzhou University (CN)
- Henan Provincial People's Hospital (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1111/cns.70372
- Citations
- 1
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- National Natural Science Foundation of China