Loss of <i>popdc3</i> Impairs Mitochondrial Function and Causes Skeletal Muscle Atrophy and Reduced Swimming Ability in Zebrafish
POPDC3, a Popeye protein, plays an important role in controlling mitochondrial function and skeletal muscle mass and strength. Loss of popdc3 decreases mitochondrial respiration and mitochondrial biogenesis, disrupting kinetic homeostasis, which induces mitochondrial dysfunction and impaired protein turnover (reduced synthesis and increased degradation), leading to zebrafish skeletal muscle atrophy.
Authors
- Xiushan Wu (ORCID: https://orcid.org/0000-0001-8431-4266)
- Xiangtao Chen (ORCID: https://orcid.org/0000-0002-5102-1472)
- Changfa Tang (ORCID: https://orcid.org/0000-0002-8104-7753)
- Dong Kwon Yang
- Zhanglin Chen (ORCID: https://orcid.org/0000-0001-9287-5119)
- Xiyang Peng (ORCID: https://orcid.org/0000-0003-1307-9785)
- Chen‐Chen Sun
- Jiang‐Ling Xiao
Institutions
- Hunan Normal University (CN)
- Hunan First Normal University (CN)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/jcsm.13794
- Citations
- 3
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Education Department of Hunan Province
- National Natural Science Foundation of China
- Hunan Normal University
- Natural Science Foundation of Hunan Province