[Analysis of the intervention effects of skill training for parents with autism child on toddlers with autism spectrum disorder].

<b>Objective:</b> To explore the intervention effects of the skill training for parents with autism child (STPAC) on toddlers with autism spectrum disorder (ASD). <b>Methods:</b> A multicenter non-randomized concurrent controlled study design was conducted. Thirty children with ASD aged 15-30 months, first diagnosed at the Children's Hospital of Fudan University, the First Hospital of Jilin University, and Chengdu Women's and Children's Central Hospital from 2019 to 2020, were enrolled in the STPAC group. Thirty children with ASD who visited the same hospitals during the same period but refused the STPAC intervention were selected as the control group. The STPAC group received an 8-week intervention (3 h/week) followed by quarterly follow-ups for 1 year, while the control group voluntarily chose community-based routine interventions. The Griffiths development scales-Chinese (GDS-C) was used to assess the developmental levels, and the communication and symbolic behavior scales developmental profile infant-toddler checklist (CSBS-DP-ITC) was completed by the primary caregivers to evaluate social, language and symbolic behavior. The independent samples <i>t</i>-tests or Mann-Whitney <i>U</i> tests, etc.was used for inter-group comparison. The paired <i>t</i>-tests or Wilcoxon signed-rank tests, etc. was used for inter-group pre-post intervention comparison. <b>Results:</b> The STPAC group included 30 children (22 males and 8 females, aged (23.9±2.2) months), and the control group included 30 children (20 males and 10 females, aged (24.2±2.6) months). Before the intervention, there were no statistically differences in GDS-C development quotient (DQ) and CSBS-DP-ITC scores between groups (all <i>P</i>>0.05). After 1-year intervention, GDS-C DQ in personal-social, hearing-language, hand-eye coordination, performance domains of STPAC group and GDS-C DQ in personal-social, hearing-language domains of control group were all increased (all <i>P</i><0.01). After 1-year intervention, CSBS-DP-ITC scores of both groups were all improved in socia, language, symbolic behavior, and total scores (all <i>P<</i>0.001). GDS-C DQ changes before and after 1 year of intervention in hearing-language, hand-eye coordination, performance domains of the STPAC group were all higher the those of control group (34(15, 48 <i>vs.</i> 10(-4, 39), 11±20 <i>vs.</i> -1±19, 23±25 <i>vs.</i> 8±22, all <i>P<</i>0.05). CSBS-DP-ITC scores changes before and after 1 year of intervention in social and total scores of the STPAC group were both higher the those of control group (10(5, 30) <i>vs.</i> 3(1, 7), 26±17 <i>vs.</i> 11±8, both <i>P<</i>0.001). <b>Conclusion:</b> Compared with the community routine interventions, the STPAC better improves the language, hand-eye coordination, visual-spatial, social communication, and play skills in ASD toddlers.