Saarvienin A—A Novel Glycopeptide with Potent Activity against Drug‐Resistant Bacteria
A member of a new family of glycopeptides, named saarvienin A, was isolated from a rare actinomycete Amycolatopsis sp. YIM10. Extensive NMR and MS analyses revealed a halogenated peptide core comprising four amino acids cyclized via a ureido linkage with an exocyclic 2-hydroxy-3-(4-hydroxyphenyl)propyl residue connected to a five-sugar/aminosugar chain. Two of the three aminosugars constitute the N-methylated and N,O-dimethylated derivatives of eremosamine (4-epi-vancosamine) that have not been reported in any natural product. Saarvienin A exhibits potent activity against a range of Gram-positive bacteria, effectively overcoming resistance to several frontline antibiotics in clinical isolates. It demonstrates an eight-fold reduction in minimum inhibitory concentrations (MICs) against methicillin-resistant, vancomycin-intermediate, and daptomycin-resistant Staphylococcus aureus compared to vancomycin.
Authors
- Bernd Morgenstern (ORCID: https://orcid.org/0000-0002-8360-4218)
- Sari Rasheed (ORCID: https://orcid.org/0000-0002-9700-0474)
- Franziska Fries (ORCID: https://orcid.org/0009-0009-6485-8317)
- Sergey B. Zotchev (ORCID: https://orcid.org/0000-0002-9324-245X)
- Jaime Felipe Guerrero Garzón (ORCID: https://orcid.org/0000-0002-1492-4816)
- Martin Zehl (ORCID: https://orcid.org/0000-0001-9685-0373)
- Rolf Müller (ORCID: https://orcid.org/0000-0002-1042-5665)
- Amninder Kaur (ORCID: https://orcid.org/0009-0007-4369-5892)
Institutions
- University of Vienna (AT)
- German Center for Infection Research (DE)
- Helmholtz Centre for Infection Research (DE)
- Helmholtz Institute for Pharmaceutical Research Saarland (DE)
- Saarland University (DE)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2025-04-18
- DOI
- https://doi.org/10.1002/anie.202425588
- Citations
- 3
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- Deutsches Zentrum für Infektionsforschung
- Universität Wien
- Universität des Saarlandes
- Universität Zürich
- Institut für Medizinische Mikrobiologie, Universität Zürich