Involvement of miRNA-204 carried by the exosomes of macrophages in the AT2 receptor-mediated improvement of vascular calcification
Our results suggested that miRNA-204-5p in exosomes secreted from macrophages was at least partly involved in the AT2 receptor-mediated improvement in VC induced by phosphate through targeting RUNX2 mRNA, inhibiting the Wnt/β-catenin signalling pathway and decreasing the expression of calcification-related proteins.
Authors
- Bao‐Shuai Shan (ORCID: https://orcid.org/0000-0003-0127-3257)
- Xiao‐Feng Lv (ORCID: https://orcid.org/0000-0001-6721-7085)
- Huijun Li (ORCID: https://orcid.org/0000-0002-2896-3867)
- Haibo Gu
- Hui‐Yu Bai
Institutions
- Soochow University (CN)
- Suzhou Municipal Hospital (CN)
- Second Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Cellular and Molecular Life Sciences
- Published
- 2025-04-18
- DOI
- https://doi.org/10.1007/s00018-025-05703-y
- Citations
- 5
- Primary Topic
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Type
- article
- Field-Weighted Citation Impact
- 8.13
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province