The m6A methyltransferase METTL3 affects ferroptosis in non-small cell lung cancer by regulating the PTEN/PI3K/AKT pathway
METTL3 may inhibit ferroptosis in NSCLC by activating the PTEN/PI3K/AKT pathway, suggesting that METTL3-mediated PTEN/PI3K/AKT pathway may be a promising therapeutic target for NSCLC.
Authors
- Jieru Xu
- Bing Wu (ORCID: https://orcid.org/0000-0003-1656-3783)
- Danhong Li (ORCID: https://orcid.org/0000-0001-6619-1194)
- Yu Wang (ORCID: https://orcid.org/0000-0003-0249-4414)
- Lihong Li
- Tingting Pan (ORCID: https://orcid.org/0009-0002-2727-3757)
Institutions
- The First People's Hospital of Xiaoshan District, Hangzhou (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-04-18
- DOI
- https://doi.org/10.1007/s12672-025-02330-8
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81